{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T14:57:02Z","timestamp":1775746622682,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:00:00Z","timestamp":1523836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI1400165"],"award-info":[{"award-number":["PI1400165"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI1401291"],"award-info":[{"award-number":["PI1401291"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Some studies have suggested that rATG<\/jats:styled-content> treatment may be associated with an increased incidence of CMV<\/jats:styled-content> infection and delayed CMV<\/jats:styled-content> immune response. However, the evidences supporting this matter are scarce. This study aims to characterize the kinetic of the CMV<\/jats:styled-content>\u2010specific T\u2010cell immune response before and after rATG<\/jats:styled-content> induction therapy and the relationship with the development of CMV<\/jats:styled-content> infection in CMV<\/jats:styled-content>\u2010seropositive kidney transplant recipients.<\/jats:p><\/jats:sec>Methods<\/jats:title>An observational prospective study of CMV<\/jats:styled-content>\u2010seropositive kidney transplant patients that received rATG<\/jats:styled-content> induction therapy was performed. A pretransplant sample was obtained before the surgery to determine the CMV<\/jats:styled-content>\u2010specific immunity. CMV<\/jats:styled-content> viral load (by PCR<\/jats:styled-content>) and CMV<\/jats:styled-content>\u2010specific T\u2010cell immune response (by flow cytometry) were determined during the follow\u2010up at 0.5, 1, 2, 3, 6, and 12\u00a0months post transplantation.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 23 patients were included in the study. CMV<\/jats:styled-content> prophylaxis was administrated for a media of 90\u00a0days after transplantation. At the end of follow\u2010up, 18 (78.3%) patients had CMV<\/jats:styled-content>\u2010specific immunity with a median value of 0.31% CD<\/jats:styled-content>8+<\/jats:sup>CD<\/jats:styled-content>69+<\/jats:sup>INF<\/jats:styled-content>\u2010\u03b3+<\/jats:sup> T cells at a median of 16\u00a0weeks post transplantation. Five patients never acquired CMV<\/jats:styled-content>\u2010specific immunity. No statistically significant association between CMV<\/jats:styled-content> infection and CMV<\/jats:styled-content>\u2010specific T\u2010cell immune response (P<\/jats:italic>\u00a0=\u00a0.086) was observed. However, patients with positive pretransplant CMV<\/jats:styled-content>\u2010specific immunity developed earlier immunity and achieved higher levels of CD<\/jats:styled-content>8+<\/jats:sup>CD<\/jats:styled-content>69+<\/jats:sup>INF<\/jats:styled-content>\u2010\u03b3+ T\u2010cell post\u2010transplantation than patients with negative pretransplant immunity.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>CMV<\/jats:styled-content>\u2010specific immune monitoring in addition to CMV<\/jats:styled-content>\u2010serology may be useful to stratify patient\u2032s risk of CMV<\/jats:styled-content> infection before transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12883","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T18:57:31Z","timestamp":1521831451000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Kinetic of the CMV<\/scp>\u2010specific T\u2010cell immune response and CMV<\/scp> infection in CMV<\/scp>\u2010seropositive kidney transplant recipients receiving rabbit anti\u2010thymocyte globulin induction therapy: A pilot study"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2022-9254","authenticated-orcid":false,"given":"Cecilia","family":"Mart\u00edn\u2010Gandul","sequence":"first","affiliation":[{"name":"Clinical Unit of Infectious Diseases, Microbiology and Medicine Preventive Instituto de Biomedicina de Sevilla (IBiS) University Hospital Virgen del Roc\u00edo\/CSIC\/University of Sevilla Sevilla Spain"},{"name":"Spanish Network for Research in Infectious Diseases (REIPI RD12\/0015\/0001; RD12\/0015\/0012; RD16\/0016\/0009) Instituto de Salud Carlos III Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3026-7905","authenticated-orcid":false,"given":"Pilar","family":"P\u00e9rez\u2010Romero","sequence":"additional","affiliation":[{"name":"Clinical Unit of Infectious Diseases, Microbiology and Medicine Preventive Instituto de Biomedicina de Sevilla (IBiS) University Hospital Virgen del Roc\u00edo\/CSIC\/University of Sevilla Sevilla Spain"},{"name":"Spanish Network for Research in Infectious Diseases (REIPI RD12\/0015\/0001; RD12\/0015\/0012; RD16\/0016\/0009) Instituto de Salud Carlos III Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dami\u00e1n","family":"Mena\u2010Romo","sequence":"additional","affiliation":[{"name":"Clinical Unit of Infectious Diseases, Microbiology and Medicine Preventive Instituto de Biomedicina de Sevilla (IBiS) University Hospital Virgen del Roc\u00edo\/CSIC\/University of Sevilla Sevilla Spain"},{"name":"Spanish Network for Research in Infectious Diseases (REIPI RD12\/0015\/0001; RD12\/0015\/0012; RD16\/0016\/0009) Instituto de Salud Carlos III Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Molina\u2010Ortega","sequence":"additional","affiliation":[{"name":"Clinical Unit of Infectious Diseases, Microbiology and Medicine Preventive Instituto de Biomedicina de Sevilla (IBiS) University Hospital Virgen del Roc\u00edo\/CSIC\/University of Sevilla Sevilla Spain"},{"name":"Spanish Network for Research in Infectious Diseases (REIPI RD12\/0015\/0001; RD12\/0015\/0012; RD16\/0016\/0009) Instituto de Salud Carlos III Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco M.","family":"Gonz\u00e1lez\u2010Roncero","sequence":"additional","affiliation":[{"name":"Clinical Unit of Nephro\u2010Urology Hospitales Universitarios Virgen del Roc\u00edo Sevilla Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Su\u00f1er","sequence":"additional","affiliation":[{"name":"Clinical Unit of Nephro\u2010Urology Hospitales Universitarios Virgen del Roc\u00edo Sevilla Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Bernal","sequence":"additional","affiliation":[{"name":"Clinical Unit of Nephro\u2010Urology Hospitales Universitarios Virgen del Roc\u00edo Sevilla Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Cordero","sequence":"additional","affiliation":[{"name":"Clinical Unit of Infectious Diseases, Microbiology and Medicine Preventive Instituto de Biomedicina de Sevilla (IBiS) University Hospital Virgen del Roc\u00edo\/CSIC\/University of Sevilla Sevilla Spain"},{"name":"Spanish Network for Research in Infectious Diseases (REIPI RD12\/0015\/0001; 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