{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:47:32Z","timestamp":1753879652250,"version":"3.41.2"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T00:00:00Z","timestamp":1525651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 CA23766"],"award-info":[{"award-number":["P01 CA23766"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FIS16\/01433"],"award-info":[{"award-number":["FIS16\/01433"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["BDNS357800"],"award-info":[{"award-number":["BDNS357800"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recipients of allogeneic hematopoietic stem cell transplantation (allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) are at high risk for invasive mold infections (<jats:styled-content style=\"fixed-case\">IMI<\/jats:styled-content>). The goal of the study is to describe the incidence and outcome of <jats:styled-content style=\"fixed-case\">IMI<\/jats:styled-content> in patients after allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> in a large cohort of patients receiving anti\u2010mold prophylaxis. We conducted a retrospective review of 988 consecutive adults who underwent allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> in our center from 2008 through 2014. Standard prophylaxis consisted of micafungin 150\u00a0mg <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> daily from admission to day +7\u00a0\u00b1\u00a03 followed by voriconazole until day +75 to +100. Cases meeting criteria for proven or probable <jats:styled-content style=\"fixed-case\">IMI<\/jats:styled-content> according to <jats:styled-content style=\"fixed-case\">EORTC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MSG<\/jats:styled-content> criteria were included. Median age at <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> was 54\u00a0years. The most common diagnoses were acute myeloid leukemia (n\u00a0=\u00a0351, 36%) and lymphoid malignancies (n\u00a0=\u00a0248, 25%). Matched related or unrelated donors (<jats:styled-content style=\"fixed-case\">URD<\/jats:styled-content>) were used in 686 (69%) patients, mismatched <jats:styled-content style=\"fixed-case\">URD<\/jats:styled-content> in 142 (14%) and cord blood units in 154 (16%). Twenty\u2010one patients were diagnosed with <jats:styled-content style=\"fixed-case\">IMI<\/jats:styled-content> after allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>, 19 probable and 2 proven, and one patient was diagnosed postmortem. Microbiological diagnosis was established in 9 cases, 5 of them being <jats:italic>Aspergillus<\/jats:italic>. One\u2010year cumulative incidence (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) of <jats:styled-content style=\"fixed-case\">IMI<\/jats:styled-content> was 1.6% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.9\u20102.5) while 12\u2010week overall survival after <jats:styled-content style=\"fixed-case\">IMI<\/jats:styled-content> was 39% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 24\u201065) Analyzed by disease, there was a trend for a higher 1\u2010year <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> of <jats:styled-content style=\"fixed-case\">IMI<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> (5% [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.6\u201011.4]) when compared with <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content> (1.4%), <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content> (1.5%) and lymphoma (1.2%), <jats:italic>P<\/jats:italic>\u00a0=\u00a0.06. The 1\u2010year <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> of <jats:styled-content style=\"fixed-case\">IMI<\/jats:styled-content> after transplantation is low in patients receiving anti\u2010mold prophylaxis with micafungin bridged to voriconazole, although these infections are associated with a higher risk of mortality.<\/jats:p>","DOI":"10.1111\/tid.12897","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T15:51:58Z","timestamp":1524066718000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Sequential systematic anti\u2010mold prophylaxis with micafungin and voriconazole results in very low incidence of invasive mold infections in patients undergoing allogeneic hematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"20","author":[{"given":"Claudia","family":"Rosillo","sequence":"first","affiliation":[{"name":"Department of Medicine Adult Bone Marrow Transplant Service Memorial Sloan Kettering Cancer Center  New York NY USA"},{"name":"Hospital Clinic Universitat de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Maria","family":"Avila","sequence":"additional","affiliation":[{"name":"Department of Medicine Adult Bone Marrow Transplant Service Memorial Sloan Kettering Cancer Center  New York NY USA"},{"name":"La Sabana School of Medicine  Bogota Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao\u2010Ting","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medicine Infectious Disease Service Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"Devlin","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Memorial Sloan Kettering Cancer Center  New York NY USA"},{"name":"Weill Cornell Medical College  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Medicine Adult Bone Marrow Transplant Service Memorial Sloan Kettering Cancer Center  New York NY USA"},{"name":"Weill Cornell Medical College  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Montoro","sequence":"additional","affiliation":[{"name":"Department of Medicine Adult Bone Marrow Transplant Service Memorial Sloan Kettering Cancer Center  New York NY USA"},{"name":"Hospital Universitario La Fe  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molly A.","family":"Maloy","sequence":"additional","affiliation":[{"name":"Department of Medicine Adult Bone Marrow Transplant Service Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genovefa A.","family":"Papanicolaou","sequence":"additional","affiliation":[{"name":"Department of Medicine Infectious Disease Service Memorial Sloan Kettering Cancer Center  New York NY USA"},{"name":"Weill Cornell Medical College  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1038-5197","authenticated-orcid":false,"given":"Pere","family":"Barba","sequence":"additional","affiliation":[{"name":"Department of Medicine Adult Bone Marrow Transplant Service Memorial Sloan Kettering Cancer Center  New York NY USA"},{"name":"Hospital Universitario Vall d'Hebron\u2010 Universitat Autonoma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel\u2010Angel","family":"Perales","sequence":"additional","affiliation":[{"name":"Department of Medicine Adult Bone Marrow Transplant Service Memorial Sloan Kettering Cancer Center  New York NY USA"},{"name":"Weill Cornell Medical College  New York NY 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Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.12897","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.12897","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T15:54:55Z","timestamp":1694966095000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.12897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,7]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/tid.12897"],"URL":"https:\/\/doi.org\/10.1111\/tid.12897","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"type":"print","value":"1398-2273"},{"type":"electronic","value":"1399-3062"}],"subject":[],"published":{"date-parts":[[2018,5,7]]},"assertion":[{"value":"2017-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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