{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:49:21Z","timestamp":1790516961698,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T00:00:00Z","timestamp":1525910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007054","name":"Meso Scale Diagnostics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is lack of recent multicenter epidemiological data on invasive aspergillosis (<jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>) among solid organ transplant recipient (<jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content>r) in the mold\u2010acting antifungal era. We describe the epidemiology and outcomes of <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> in a contemporary cohort of <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content>r using the Swiss Transplant Cohort Study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All consecutive <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content>r with proven or probable <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> between 01.05.2008 and 31.12.2014 were included. A case\u2010control study to identify <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> predictors was performed: 1\u2010case was matched with 3\u2010controls based on <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content> type, transplant center, and time post\u2010<jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 2868 <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content>r, 70 (2.4%) patients were diagnosed with proven (N:\u00a030\/70, 42.9%) or probable (N: 40\/70, 57.1%) <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>. The incidence of <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> was 8.3%, 7.1%, 2.6%, 1.3%, and 1.2% in lung, heart, combined, kidney, and liver transplant recipients, respectively, Galactomannan immunoassay was positive in 1\/3 of patients tested. Only 33\/63 (52.4%) of patients presented with typical pulmonary radiographic findings. Predictors of <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> included: renal insufficiency, re\u2010operation, and bacterial and viral infections. 12\u2010week mortality was higher in liver (85.7%, 6\/7) compared to other (15.9%, 10\/63; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.001) <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content>r.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Invasive aspergillosis remains a rare complication post\u2010<jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content>, with atypical radiographic presentations and low positivity rates of biomarkers posing significant diagnostic challenges. Although overall mortality has decreased in <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content>r, it remains high in liver <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content>r.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12898","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T15:56:54Z","timestamp":1524067014000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["Epidemiology, risk factors and outcomes of invasive aspergillosis in solid organ transplant recipients in the Swiss Transplant Cohort Study"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6970-2869","authenticated-orcid":false,"given":"D.","family":"Neofytos","sequence":"first","affiliation":[{"name":"Transplant Infectious Diseases Unit University Hospitals of Geneva  Geneva 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