{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T04:14:00Z","timestamp":1778732040434,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T00:00:00Z","timestamp":1527120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2018,8]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Cytomegalovirus (CMV<\/jats:styled-content>) is the most common viral infection in liver transplant recipients that influences the outcomes of liver transplantation. However, its impact on early outcomes following living donor liver transplantation (LDLT<\/jats:styled-content>) is not fully defined in the Indian subcontinent. This study was done to assess the impact of CMV<\/jats:styled-content> infection on early post\u2010transplant outcomes in LDLT<\/jats:styled-content> recipients.<\/jats:p><\/jats:sec>Methods<\/jats:title>Out of 272 LDLT<\/jats:styled-content>s performed from January 2012 to April 2013, 151 recipients underwent CMV<\/jats:styled-content> viral load analysis in plasma within 90\u00a0days post LDLT<\/jats:styled-content> based on clinical suspicion. Patients with CMV<\/jats:styled-content> infection (n\u00a0=\u00a055) were compared with those without CMV<\/jats:styled-content> infection (n\u00a0=\u00a096).<\/jats:p><\/jats:sec>Results<\/jats:title>The median time interval of CMV<\/jats:styled-content> infection from LDLT<\/jats:styled-content> was 25\u00a0days (range 2\u201090\u00a0days). The mean age of study population was 48.92\u00a0years. About 116 (76.8%) of the patients were male. Hepatitis C virus (HCV<\/jats:styled-content>) (39.1%)\u2010related chronic liver disease (CLD<\/jats:styled-content>) was most common indication for liver transplant. No statistically significant difference was observed in etiology of liver disease (P<\/jats:italic>\u00a0=\u00a0.38), Chid\u2010Turcotte\u2010Pugh (CTP<\/jats:styled-content>) (P<\/jats:italic>\u00a0=\u00a0.41), and Model for End\u2010stage Liver Disease (MELD<\/jats:styled-content>) (P<\/jats:italic>\u00a0=\u00a0.12) scores between the groups. Patients with CMV<\/jats:styled-content> infection had significantly higher incidence of acute cellular rejection (16.1% vs 5.4%, P<\/jats:italic>\u00a0=\u00a0.02); longer ICU<\/jats:styled-content> stay (P<\/jats:italic>\u00a0=\u00a0.01); and a higher overall 90\u2010day mortality (24.2% vs 6.7%, P<\/jats:italic>\u00a0=\u00a0.001). Bacteremia and fungemia were significantly more common in the CMV<\/jats:styled-content> infection group.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Cytomegalovirus infection significantly influences the early post LDLT<\/jats:styled-content> outcomes and contributes to increased overall mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12905","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T16:09:42Z","timestamp":1524067782000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cytomegalovirus infection in living donor liver transplant recipients significantly impacts the early post\u2010transplant outcome: A single center experience"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8998-9633","authenticated-orcid":false,"given":"Sanjay Kumar","family":"Yadav","sequence":"first","affiliation":[{"name":"Institute of Liver Transplantation and Regenerative Medicine Medanta, The Medicity Gurgaon Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjiv","family":"Saigal","sequence":"additional","affiliation":[{"name":"Institute of Liver Transplantation and Regenerative Medicine Medanta, The Medicity Gurgaon Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narendra Singh","family":"Choudhary","sequence":"additional","affiliation":[{"name":"Institute of Liver Transplantation and Regenerative Medicine Medanta, The Medicity Gurgaon Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujeet","family":"Saha","sequence":"additional","affiliation":[{"name":"Institute of Liver Transplantation and Regenerative Medicine Medanta, The Medicity Gurgaon Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayant Kumar","family":"Sah","sequence":"additional","affiliation":[{"name":"Institute of Liver Transplantation and Regenerative Medicine Medanta, The Medicity Gurgaon Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neeraj","family":"Saraf","sequence":"additional","affiliation":[{"name":"Institute of Liver Transplantation and Regenerative Medicine Medanta, The Medicity Gurgaon Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naveen","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Microbiology Medanta, The Medicity Gurgaon Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Goja","sequence":"additional","affiliation":[{"name":"Institute of Liver Transplantation and Regenerative Medicine Medanta, The Medicity Gurgaon Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Rastogi","sequence":"additional","affiliation":[{"name":"Institute of Liver Transplantation and Regenerative Medicine Medanta, The Medicity Gurgaon Delhi 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