{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:20:29Z","timestamp":1787016029840,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T00:00:00Z","timestamp":1525824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2018,8]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Immune\u2010compromised patients with latent\n TB<\/jats:styled-content>\n infection (\n LTBI<\/jats:styled-content>\n ) are at risk for\n TB<\/jats:styled-content>\n reactivation and should receive prophylaxis. Whereas the tuberculin skin test (\n TST<\/jats:styled-content>\n ) has limitations particularly in immune\u2010compromised patients.\n <\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n \n This retrospective study was conducted to determine the incidence of\n TB<\/jats:styled-content>\n infection in adult\n HSCT<\/jats:styled-content>\n recipients whose preventive therapy for\n LTBI<\/jats:styled-content>\n was determined according to the guidance of targeted\n TST<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n Five hundred and fifty\u2010eight consecutive\n HSCT<\/jats:styled-content>\n recipients (287 autologous and 271 allogeneic) who survived \u2265100\u00a0days post\u2010transplantation were included in this analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Tuberculin skin test results were available in 493 of 558 transplants (88.3%). The incidence of negative\n TST<\/jats:styled-content>\n was 54.5% (269 of 493 patients). One multiple myeloma patient with a history of\n TB<\/jats:styled-content>\n and negative\n TST<\/jats:styled-content>\n result and was not on\n INH<\/jats:styled-content>\n prophylaxis developed reactivation of\n TB<\/jats:styled-content>\n infection. None of the recipients under\n INH<\/jats:styled-content>\n prophylaxis (151 of 558 transplants; 27.1%) and none of the 224 patients with\n TST<\/jats:styled-content>\n \u22655\u00a0mm developed\n TB<\/jats:styled-content>\n infection.\n <\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n \n Despite the limitations of being a retrospective analysis and variable prophylaxis thresholds of\n TST<\/jats:styled-content>\n , there are some remarkable results of this analysis. We had no\n TB<\/jats:styled-content>\n infection in the allogeneic\n HSCT<\/jats:styled-content>\n recipients. The high incidence of negative\n TST<\/jats:styled-content>\n results may be attributed to the underlying immune\u2010deficiency.\n TST<\/jats:styled-content>\n may not be a reliable guide for predicting\n TB<\/jats:styled-content>\n reactivation risk in hematology patients.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Tuberculin skin test may have a high rate of false\u2010negative and false\u2010positive results in\n HSCT<\/jats:styled-content>\n recipients. The general guidelines for targeted\n TST<\/jats:styled-content>\n to guide treatment of\n LTBI<\/jats:styled-content>\n may not apply to all regions and situations. More reliable methods are required to predict and treat\n LTBI<\/jats:styled-content>\n in these specific conditions.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/tid.12912","type":"journal-article","created":{"date-parts":[[2018,4,21]],"date-time":"2018-04-21T09:44:54Z","timestamp":1524303894000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The incidence of tuberculosis infection in hematopoietic stem cell transplantation recipients: A retrospective cohort study from a center in Turkey"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3068-5085","authenticated-orcid":false,"given":"\u015eahika Zeynep","family":"Ak\u0131","sequence":"first","affiliation":[{"name":"Departments of Hematology Faculty of Medicine Gazi University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fclsan T\u00fcrk\u00f6z","family":"Sucak","sequence":"additional","affiliation":[{"name":"Departments of Hematology Faculty of Medicine Gazi University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem G\u00fczel","family":"Tun\u00e7can","sequence":"additional","affiliation":[{"name":"Departments of Infectious Disease Faculty of Medicine Gazi University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurdan","family":"K\u00f6kt\u00fcrk","sequence":"additional","affiliation":[{"name":"Departments of Pulmonary Disease Faculty of Medicine Gazi University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esin","family":"\u015eenol","sequence":"additional","affiliation":[{"name":"Departments of Infectious Disease Faculty of Medicine Gazi University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,9]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"World Health Organization (WHO).http:\/\/apps.who.int\/gho\/data. Accessed January 10 2014."},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/17.6.968"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.supplement_3.ats600"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704636"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2005.09.020"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/383307"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2013.061"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2009.08.001"},{"key":"e_1_2_5_10_1","first-page":"59","article-title":"Incidence of tuberculosis after bone marrow transplantation in a single center from Turkey","volume":"29","author":"Arslan \u00d6","year":"1998","journal-title":"Haematologia"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2007.00679.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1083-8791(00)70013-9"},{"key":"e_1_2_5_13_1","first-page":"1","article-title":"Guidelines for the investigation of contacts of persons with infectious tuberculosis. Reommendations from the national tuberculosis controllers association and CDC","volume":"16","author":"Taylor Z","year":"2005","journal-title":"CDC Recomm Rep"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1532\/IJH97.A10219"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.14.0301"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702506"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-0711-6-16"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705129"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701930"},{"key":"e_1_2_5_20_1","unstructured":"\u201cTuberculosis Report of Turkey in 2012\u201d National Public Health Agency Ministry of Health Press No 884 Ankara Turkey 2012."},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00000712"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00115110"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00114810"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-149-3-200808050-00241"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00028510"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.12912","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.12912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T11:52:52Z","timestamp":1694951572000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.12912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,9]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/tid.12912"],"URL":"https:\/\/doi.org\/10.1111\/tid.12912","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,9]]},"assertion":[{"value":"2017-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12912"}}