{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T06:17:46Z","timestamp":1772000266076,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T00:00:00Z","timestamp":1526256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our primary objective was to describe the incidence of proven or probable invasive fungal infections (<jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>s), a devastating complication of hematopoietic stem cell transplant (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>), in <jats:styled-content style=\"fixed-case\">HCST<\/jats:styled-content> in a middle\u2010income country. Secondary objectives were to describe factors associated with <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>s and outcomes. In this single center retrospective study, pediatric patients who underwent a first allogeneic or autologous <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> from 1998 to 2016 were included. Of the 251 <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> recipients: 143 transplants were allogeneic and 108 were autologous. Overall, 23 (9%) experienced an <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>, mostly due to yeasts (83%). <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>s were more common in allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> (18\/143, 13%) than in autologous <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> (5\/108, 5%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.045). Of the 23 patients with <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>s, 14 (61%) died, but only 1 directly from <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content> (pulmonary aspergillosis). Overall survival at 3\u00a0years was 0.42\u00a0\u00b1\u00a00.11 in patients with <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>s and 0.60\u00a0\u00b1\u00a00.37 in those without <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>s (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.049). In Argentina, <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>s during <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> are common. Recipients of allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> are at higher risk, and <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content> is associated with reduced overall survival. Future work should focus on interventions to reduce and improve <jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content> outcomes in children undergoing transplants in low\u2010 and middle\u2010income countries.<\/jats:p>","DOI":"10.1111\/tid.12913","type":"journal-article","created":{"date-parts":[[2018,4,21]],"date-time":"2018-04-21T00:32:05Z","timestamp":1524270725000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Fungal infections in hematopoietic stem cell transplantation in children at a pediatric children\u2019s hospital in Argentina"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6198-9778","authenticated-orcid":false,"given":"Sergio M.","family":"Gomez","sequence":"first","affiliation":[{"name":"Stem Cell Transplantation Unit Hospital de Ni\u00f1os Sor Mar\u00eda Ludovica  La Plata Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguela","family":"Caniza","sequence":"additional","affiliation":[{"name":"Global Pediatric Medicine Infectious Diseases. 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