{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:24:16Z","timestamp":1790267056187,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T00:00:00Z","timestamp":1529539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2018,8]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>BK<\/jats:styled-content> polyomavirus can lead to hemorrhagic cystitis (BKP<\/jats:styled-content>yV\u2010HC<\/jats:styled-content>) in allogeneic stem cell transplantation and therefore to increased morbidity. No causal therapy has been established yet. Cidofovir (CDV<\/jats:styled-content>) is a nucleotide analog of cytosine that is active against various DNA<\/jats:styled-content> viruses and it has been described for therapy of BKP<\/jats:styled-content>yV\u2010HC<\/jats:styled-content> using 2 admission routes: intravenous and intravesical.<\/jats:p><\/jats:sec>Methods<\/jats:title>We performed a systematic review regarding the comparison of intravenous or intravesical cidofovir in the treatment of BKP<\/jats:styled-content>yV\u2010HC<\/jats:styled-content> following adult allogeneic stem cell transplantation. Since there is a lack of randomized controlled trials, we considered all kinds of studies for this review. Due to heterogeneity of the data, we were not able to perform a meta\u2010analysis, so the results are shown descriptively.<\/jats:p><\/jats:sec>Results<\/jats:title>The literature search for primary studies yielded 232 results. Finally, 9 studies where considered which included a total of 189 adult patients with BKP<\/jats:styled-content>yV\u2010HC<\/jats:styled-content> after allogeneic stem cell transplantation. We could only identify retrospective studies for this review. A total of 172 patients received intravenous CDV<\/jats:styled-content>, 17 patients received intravesical CDV<\/jats:styled-content>, and 2 patients received CDV<\/jats:styled-content> in both admission routes. In 68.0% of the cases, a complete response for intravenous CDV<\/jats:styled-content> was documented and in 88.2% for intravesical CDV<\/jats:styled-content>. Interestingly, no kidney toxicity was mentioned in intravesical CDV<\/jats:styled-content>. 9.3% of the intravenously treated patients had renal failure.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>There is only weak evidence for the use of CDV<\/jats:styled-content>. The intravesical admission route should be further investigated because of a good toxicity profile.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12914","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T14:35:06Z","timestamp":1527172506000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Comparison of intravenous or intravesical cidofovir in the treatment of BK<\/scp> polyomavirus\u2010associated hemorrhagic cystitis following adult allogeneic stem cell transplantation\u2014A systematic review"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3409-8654","authenticated-orcid":false,"given":"Laila","family":"Schneidewind","sequence":"first","affiliation":[{"name":"Department of Haematology\/Oncology University Medicine Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1160-1277","authenticated-orcid":false,"given":"Thomas","family":"Neumann","sequence":"additional","affiliation":[{"name":"Department of Haematology\/Oncology University Medicine Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian Andreas","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Haematology\/Oncology University Medicine Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Kr\u00fcger","sequence":"additional","affiliation":[{"name":"Department of Haematology\/Oncology University Medicine Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701555"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-017-2935-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.11.5394-5396.2004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3062.2001.003001044.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13635"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2013.235"},{"key":"e_1_2_8_8_1","first-page":"23","article-title":"Cidofovir in the treatment of BK virus\u2010associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation","volume":"4","author":"Philippe M","year":"2016","journal-title":"Biol Blood Marrow Transplant"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000345852"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/427291"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2014.205"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2009.258"},{"key":"e_1_2_8_13_1","first-page":"12","article-title":"ECIL guidelines for the prevention, diagnosis and treatment of BK polyomavirus\u2010associated haemorrhagic cystitis in haematopoietic stem cell transplant recipeients","volume":"73","author":"Cesaro S","year":"2018","journal-title":"J Antimicrob Chemother"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2010.00513.x"},{"key":"e_1_2_8_15_1","volume-title":"Principles and Practice of Infectious Diseases. 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