{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T03:34:40Z","timestamp":1776483280848,"version":"3.51.2"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T00:00:00Z","timestamp":1528848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2018,8]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The use of mTOR<\/jats:styled-content> inhibitors is associated with lower incidence of CMV<\/jats:styled-content> infections but its effect on viral load has not been investigated.<\/jats:p><\/jats:sec>Aims, Materials and Methods<\/jats:title>This post\u2010hoc analysis included data from 273 CMV<\/jats:styled-content> seropositive kidney transplant recipients randomized to receive anti\u2010thymocyte globulin and everolimus (rAGT<\/jats:styled-content>\/TAC<\/jats:styled-content>\/EVR<\/jats:styled-content>, n\u00a0=\u00a081), basiliximab and everolimus (BAS<\/jats:styled-content>\/TAC<\/jats:styled-content>\/EVR<\/jats:styled-content>, n\u00a0=\u00a097) or basiliximab and mycophenolate (BAS<\/jats:styled-content>\/TAC<\/jats:styled-content>\/MPS<\/jats:styled-content>, n\u00a0=\u00a095). All patients received tacrolimus (TAC<\/jats:styled-content>) and corticosteroids. Preemptive CMV<\/jats:styled-content> therapy based on weekly pp65 antigenemia test was used during the first 6\u00a0months. Blinded weekly CMV DNA<\/jats:styled-content>emia was compared among the groups.<\/jats:p><\/jats:sec>Results<\/jats:title>The proportion of patients with undetectable CMV DNA<\/jats:styled-content>emia (23.4% vs 56.7% vs 22.1%, P<\/jats:italic>\u00a0<\u00a0.001) was higher in the BAS<\/jats:styled-content>\/TAC<\/jats:styled-content>\/EVR<\/jats:styled-content>. The median number of study visits with positive CMV DNA<\/jats:styled-content>emia (2.0 vs 0.0 vs 4.6, rATG<\/jats:styled-content>\/EVR<\/jats:styled-content> vs BAS<\/jats:styled-content>\/MPS<\/jats:styled-content>, P<\/jats:italic>\u00a0=\u00a0.354; BAS<\/jats:styled-content>\/EVR<\/jats:styled-content> vs BAS<\/jats:styled-content>\/MPS<\/jats:styled-content>, P<\/jats:italic>\u00a0<\u00a0.0001; rATG<\/jats:styled-content>\/EVR<\/jats:styled-content> vs BAS<\/jats:styled-content>\/EVR<\/jats:styled-content>, P<\/jats:italic>\u00a0<\u00a0.001) were lower in the BAS<\/jats:styled-content>\/TAC<\/jats:styled-content>\/EVR<\/jats:styled-content>. The proportion of patients with positive CMV DNA<\/jats:styled-content>emia who were not treat for CMV<\/jats:styled-content> infection\/disease based on pp65 antigenemia was higher in rATG<\/jats:styled-content>\/TAC<\/jats:styled-content>\/EVR<\/jats:styled-content> group (74.1% vs 36.1% vs 44.2%, P<\/jats:italic>\u00a0<\u00a0.001) but mean CMV DNA<\/jats:styled-content>emia was comparable to BAS<\/jats:styled-content>\/TAC<\/jats:styled-content>\/EVR<\/jats:styled-content> and lower than BAS<\/jats:styled-content>\/TAC<\/jats:styled-content>\/MPS<\/jats:styled-content> (8536\u00a0\u00b1\u00a015\u00a0899 vs 7975\u00a0\u00b1\u00a017\u00a0935 vs 16\u00a0965\u00a0\u00b1\u00a037\u00a0694 copies\/mL, P<\/jats:italic>\u00a0<\u00a0.05), respectively. The proportion of patients with CMV DNA<\/jats:styled-content>emia below 5000 copies\/mL was higher in patients receiving EVR<\/jats:styled-content> (74.1% vs 83.5% vs 50.0%, P<\/jats:italic>\u00a0=\u00a0.000), respectively.<\/jats:p><\/jats:sec>Discussion and Conclusion<\/jats:title>These data suggest that mTOR<\/jats:styled-content> inhibitors reduce the incidence of CMV<\/jats:styled-content> infection by limiting CMV<\/jats:styled-content> viral replication.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12919","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T17:50:05Z","timestamp":1527184205000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The effect of anti\u2010thymocyte globulin and everolimus on the kinetics of cytomegalovirus viral load in seropositive kidney transplant recipients without 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