{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T23:13:23Z","timestamp":1785194003251,"version":"3.55.0"},"reference-count":58,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T00:00:00Z","timestamp":1530144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008593","name":"European Respiratory Society","doi-asserted-by":"publisher","award":["STRTF 2014\u20107178"],"award-info":[{"award-number":["STRTF 2014\u20107178"]}],"id":[{"id":"10.13039\/100008593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2018,10]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Sinus disease (SD<\/jats:styled-content>) in cystic fibrosis (CF<\/jats:styled-content>) is a known risk factor for disease progression, the upper airways (UAW<\/jats:styled-content>) being a site of primary colonization with Pseudomonas aeruginosa<\/jats:italic>. UAW<\/jats:styled-content> may function as reservoir for graft colonization after lung transplantation (LuTx), increasing risk of rejection. Aims of this study were to assess the burden of sinus disease in CF<\/jats:styled-content> LuTx recipients, considering patient\u2010reported symptoms, endoscopically documented signs and microbiological isolates, comparing colonization between upper and lower airways.<\/jats:p><\/jats:sec>Methods<\/jats:title>A prospective, observational study was performed on consecutive CF<\/jats:styled-content> LuTx recipients, recording history, symptoms, and management of SD<\/jats:styled-content>. Nasal lavage (NL<\/jats:styled-content>) was evaluated for UAW<\/jats:styled-content> colonization, with nasal inspection during bronchoscopy and bronchoalveolar lavage (BAL<\/jats:styled-content>) used to assess lower airways if clinically indicated.<\/jats:p><\/jats:sec>Results<\/jats:title>Hundred and fifty\u2010four patients were included. Symptoms of SD<\/jats:styled-content> were reported in 96 (62%) individuals; 87 (56%) had prior sinus surgery. Only 8 (13%) of 60 individuals undergoing bronchoscopy presented completely normal findings of the nasal cavity. Thirty\u2010six (60%) patients presented the same isolates on both NL<\/jats:styled-content> and BAL<\/jats:styled-content>. Polyps and mucosal alterations were significantly less frequently seen endoscopically in patients with normal flora in NL<\/jats:styled-content> microbiology (respectively, 26% vs 70%, P<\/jats:italic>\u00a0=\u00a0.003, and 35% vs 68%, P<\/jats:italic>\u00a0=\u00a0.013).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Symptoms of SD<\/jats:styled-content> affected more than 60% of CF<\/jats:styled-content> LuTx recipients. Nasal endoscopic inspection identified alterations in 55%. The majority of patients presented the same isolates both on NL<\/jats:styled-content> and BAL<\/jats:styled-content> performed on the same visit. These results strongly support a role of paranasal sinuses as \u201creservoir\u201d for descending re\u2010colonization of the lung graft.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12924","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T14:11:30Z","timestamp":1527171090000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The burden of sinus disease in cystic fibrosis lung transplant recipients"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4661-6471","authenticated-orcid":false,"given":"Letizia Corinna","family":"Morlacchi","sequence":"first","affiliation":[{"name":"Internal Medicine Department Respiratory Unit and Cystic Fibrosis Adult Centre Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico di Milano Milan Italy"},{"name":"Department of Pathophysiology and Transplantation Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Greer","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Lungentransplantation Hannover Medical School Hanover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Tudorache","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic, Transplant and Vascular Surgery Hannover Medical School Hanover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Blasi","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Respiratory Unit and Cystic Fibrosis Adult Centre Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico di Milano Milan Italy"},{"name":"Department of Pathophysiology and Transplantation Universit\u00e0 degli Studi di Milano Milan 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