{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T04:07:48Z","timestamp":1776830868619,"version":"3.51.2"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T00:00:00Z","timestamp":1528848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000035","name":"Institute of Nutrition, Metabolism and Diabetes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intravesical Bacillus Camlette\u2010Gu\u00e9rin (<jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>) is the treatment of choice for non\u2010muscle invasive bladder cancer, and has been used successfully for over 40\u00a0years. A rare and potentially fatal complication of intravesical<jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>therapy is<jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>\u2010induced sepsis. We report a rare case in which a patient with end\u2010stage renal disease secondary to chronic granulomatous interstitial nephritis underwent remote, pre\u2010transplant intravesical<jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>treatment for high\u2010grade non\u2010invasive papillary bladder carcinoma. The patient subsequently received a deceased donor kidney transplant 5\u00a0years after<jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>therapy, with thymoglobulin induction therapy and standard triple maintenance immunosuppression. Two years post\u2010transplant, he developed<jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>\u2010induced sepsis confirmed by cultures from urine, blood, and left native kidney biopsy. He died from disseminated<jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>\u2010induced sepsis and failure of his renal allograft. This case highlights the potential adverse reactions associated with intravesical<jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>therapy that may occur years after bladder cancer therapy is completed, and should heighten physician awareness for<jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>\u2010related infections during pre\u2010transplant assessment and post\u2010transplant care of solid organ transplants recipients.<\/jats:p>","DOI":"10.1111\/tid.12931","type":"journal-article","created":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T20:45:25Z","timestamp":1527626725000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Disseminated<i>Mycobacterium bovis<\/i>infection post\u2010kidney transplant following remote intravesical<scp>BCG<\/scp>therapy for bladder cancer"],"prefix":"10.1111","volume":"20","author":[{"given":"Jennifer","family":"Ziegler","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Rady Faculty of Health Sciences University of Manitoba Winnipeg MB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8342-9093","authenticated-orcid":false,"given":"Julie","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rady Faculty of Health Sciences University of Manitoba Winnipeg MB Canada"},{"name":"Department of Immunology University of Manitoba Winnipeg MB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian W.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Pathology Rady Faculty of Health Sciences University of Manitoba Winnipeg MB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmir G.","family":"Nayak","sequence":"additional","affiliation":[{"name":"Department of Surgery Section of Urology University of Manitoba Winnipeg MB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Stein","sequence":"additional","affiliation":[{"name":"Diagnostic Services Manitoba Medical Microbiology Winnipeg MB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Walkty","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rady Faculty of Health Sciences University of Manitoba Winnipeg MB Canada"},{"name":"Diagnostic Services Manitoba Medical Microbiology Winnipeg MB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Orr","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rady Faculty of Health Sciences University of Manitoba Winnipeg MB Canada"},{"name":"Department of Medical Microbiology Rady\u00a0Faculty of Health Sciences University of Manitoba Winnipeg MB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,13]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"FinePEM CarneiroIAM MilstienJB ClementsCJ.Issues relating to the use of BCG in immunization programmes. 1999.http:\/\/apps.who.int\/iris\/bitstream\/10665\/66120\/1\/WHO_V_B_99.23.pdf. 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