{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:12:09Z","timestamp":1771470729214,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T00:00:00Z","timestamp":1532563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Kidney transplant recipients (<jats:styled-content style=\"fixed-case\">KTR<\/jats:styled-content>s) are at risk for reactivation and complicated infection due to <jats:italic>Coccidioides<\/jats:italic>. Pre\u2010transplant serological screening should provide benefit for patients from endemic areas. We evaluated <jats:italic>Coccidioides<\/jats:italic> seroprevalence by area of residence in <jats:styled-content style=\"fixed-case\">KTR<\/jats:styled-content>s at a major transplant program in Los Angeles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed cross\u2010sectional analyses of adult <jats:styled-content style=\"fixed-case\">KTR<\/jats:styled-content>s who underwent transplantation at <jats:styled-content style=\"fixed-case\">UCLA<\/jats:styled-content> between 2007\u20102016. Patients with <jats:italic>Coccidioides<\/jats:italic> serology by enzyme immunoassay (<jats:styled-content style=\"fixed-case\">EIA<\/jats:styled-content>) before or within 14\u00a0days from transplantation were included. Patients were classified as living in highly, established, suspected, or not endemic areas by their residential zip code.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall prevalence of <jats:italic>Coccidioides<\/jats:italic> IgG and IgM were 1.4% and 2.8%, respectively. Of patients with positive serology, 31.4% had isolated IgG and 66.3% isolated IgM. Patients from established and highly endemic areas had IgG seropositivity of 3.7% versus 1.3% for patients living in suspected endemic areas(<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). Rates of IgM seropositivity were 3.7% compared to 2.8% respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.28). No patients from non\u2010endemic areas had positive screening serology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pre\u2010transplant serological screening for <jats:italic>Coccidioides<\/jats:italic> is recommended in kidney transplant candidates from endemic areas. We observed high seroprevalence among patients from highly and established endemic areas, for whom universal prophylaxis is recommended. For residents from less well\u2010established areas of endemicity, serological screening showed benefit in identifying patients at risk. In patients with isolated <jats:styled-content style=\"fixed-case\">EIA<\/jats:styled-content> IgM, performing repeat and confirmatory tests is recommended. Patients from non\u2010endemic areas had low risk of infection, however, a thorough social history is necessary to evaluate risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12932","type":"journal-article","created":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T20:45:26Z","timestamp":1527626726000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Screening <i>Coccidioides<\/i> serology in kidney transplant recipients: A 10\u2010year cross\u2010sectional analysis"],"prefix":"10.1111","volume":"20","author":[{"given":"Korntip","family":"Phonphok","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Nephrology Kidney and Pancreas Transplant Research Center David Geffen School of Medicine at UCLA  Los Angeles CA USA"},{"name":"Department of Medicine Division of Nephrology Rajavithi Hospital  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer","family":"Beaird","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Infectious Diseases David Geffen School of Medicine at UCLA  Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tin","family":"Duong","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Nephrology Kidney and Pancreas Transplant Research Center David Geffen School of Medicine at UCLA  Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nakul","family":"Datta","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Nephrology Kidney and Pancreas Transplant Research Center David Geffen School of Medicine at UCLA  Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1174-3961","authenticated-orcid":false,"given":"Joanna","family":"Schaenman","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Infectious Diseases David Geffen School of Medicine at UCLA  Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1668-2005","authenticated-orcid":false,"given":"Suphamai","family":"Bunnapradist","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Nephrology Kidney and Pancreas Transplant Research Center David Geffen School of Medicine at UCLA  Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,26]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"185","article-title":"Coccidioidomycosis: epidemiology","volume":"5","author":"Brown J","year":"2013","journal-title":"Clin Epidemiol"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw360"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12117"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.31.1.35"},{"key":"e_1_2_9_6_1","unstructured":"Coccidioidomycosis | Types of Fungal Diseases | Fungal | CDC.https:\/\/www.cdc.gov\/fungal\/diseases\/coccidioidomycosis\/index.html. 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