{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:24:58Z","timestamp":1791959098337,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T00:00:00Z","timestamp":1529020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There were 13 documented clusters of infectious encephalitis transmission via organ transplant from deceased donors to recipients during 2002\u20102013. Hence, organs from donors diagnosed with encephalitis are often declined because of concerns about the possibility of infection, given that there is no quick and simple test to detect causes of infectious encephalitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We constructed a database containing cases of infectious and non\u2010infectious encephalitis. Using statistical imputation, cross\u2010validation, and regression techniques, we determined deceased organ donor characteristics, including demographics, signs, symptoms, physical exam, and laboratory findings, predictive of infectious vs non\u2010infectious encephalitis, and developed a calculator which assesses the risk of infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Using up to 12 predictive patient characteristics (with a minimum of 3, depending on what information is available), the calculator provides the probability that a donor may have infectious vs non\u2010infectious encephalitis, improving the prediction accuracy over current practices. These characteristics include gender, fever, immunocompromised state (other than <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>), cerebrospinal fluid elevation, altered mental status, psychiatric features, cranial nerve abnormality, meningeal signs, focal motor weakness, Babinski's sign, movement disorder, and sensory abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the absence of definitive diagnostic testing in a potential organ donor, infectious encephalitis can be predicted with a risk score. The risk calculator presented in this paper represents a prototype, establishing a framework that can be expanded to other infectious diseases transmissible through solid organ transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12933","type":"journal-article","created":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T20:45:45Z","timestamp":1527626745000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Assessment of risk for transplant\u2010transmissible infectious encephalitis among deceased organ donors"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0275-1807","authenticated-orcid":false,"given":"Hannah K.","family":"Smalley","sequence":"first","affiliation":[{"name":"H. Milton Stewart School of Industrial and Systems Engineering Georgia Institute of Technology  Atlanta GA USA"},{"name":"Center for Health and Humanitarian Systems Georgia Institute of Technology  Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishi","family":"Anand","sequence":"additional","affiliation":[{"name":"H. Milton Stewart School of Industrial and Systems Engineering Georgia Institute of Technology  Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Buczek","sequence":"additional","affiliation":[{"name":"H. Milton Stewart School of Industrial and Systems Engineering Georgia Institute of Technology  Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Buczek","sequence":"additional","affiliation":[{"name":"H. Milton Stewart School of Industrial and Systems Engineering Georgia Institute of Technology  Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Lin","sequence":"additional","affiliation":[{"name":"H. Milton Stewart School of Industrial and Systems Engineering Georgia Institute of Technology  Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanay","family":"Rajore","sequence":"additional","affiliation":[{"name":"H. Milton Stewart School of Industrial and Systems Engineering Georgia Institute of Technology  Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Wacker","sequence":"additional","affiliation":[{"name":"H. 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