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No cases of such a complication have been reported in hematopoietic stem cell transplant (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) recipients. We present a 65\u2010year male who underwent autologous <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> for the treatment of multiple myeloma. Prior to transplant he was started on single agent tenofovir alafenamide (<jats:styled-content style=\"fixed-case\">TAF<\/jats:styled-content>) for treatment of resolved hepatitis B infection. He presented few weeks later with severe lactic acidosis. Other causes of lactic acidosis were excluded. The patient died of multi\u2010organ failure despite stopping <jats:styled-content style=\"fixed-case\">TAF<\/jats:styled-content> and aggressive supportive care. The case demonstrates the need for increased awareness of this potential complication of <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content> treatment in the course of transplantation.<\/jats:p>","DOI":"10.1111\/tid.12960","type":"journal-article","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T16:10:15Z","timestamp":1530807015000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Tenofovir alafenamide associated fatal lactic acidosis in an autologous hematopoietic stem cell transplant recipient"],"prefix":"10.1111","volume":"20","author":[{"given":"Sammar R.","family":"Alsunaid","sequence":"first","affiliation":[{"name":"Division of Pulmonary Critical Care and Sleep Medicine Wayne State University School of Medicine  Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Humayun","family":"Ashraf","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Critical Care and Sleep Medicine Wayne State University School of Medicine  Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0262-4365","authenticated-orcid":false,"given":"Ayman O.","family":"Soubani","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Critical Care and Sleep Medicine Wayne State University School of Medicine  Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,18]]},"reference":[{"key":"e_1_2_4_2_1","unstructured":"WHO Global Hepatitis Report 2017.http:\/\/www.who.int\/hepatitis\/publications\/global-hepatitis-report2017. 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