{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:29:08Z","timestamp":1791959348776,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T00:00:00Z","timestamp":1532044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although the research is limited, treatment guidelines recommend lifelong suppressive azole therapy for disseminated endemic fungal infection (<jats:styled-content style=\"fixed-case\">EFI<\/jats:styled-content>) after solid organ transplantation (<jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content>). Suppressive azole therapy may prevent <jats:styled-content style=\"fixed-case\">EFI<\/jats:styled-content> recurrence at the risk of hepatotoxicity and drug interactions. We present real\u2010world safety and effectiveness data of chronic suppressive azole therapy for <jats:styled-content style=\"fixed-case\">EFI<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content> recipients over a 10\u2010year period at a single comprehensive transplant center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was conducted of <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content> recipients diagnosed with <jats:styled-content style=\"fixed-case\">EFI<\/jats:styled-content> from January 1, 2005, to May 1, 2015. Chronic suppressive azole therapy was defined as treatment for more than 12\u00a0months after diagnosis. Effectiveness of suppression was defined as preventing <jats:styled-content style=\"fixed-case\">EFI<\/jats:styled-content> reactivation. Safety endpoints included adverse reactions and drug interactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over a 10\u2010year period, 28 <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content> recipients were diagnosed with <jats:styled-content style=\"fixed-case\">EFI<\/jats:styled-content>: 16 histoplasmosis, 9 blastomycosis, and 3 coccidioidomycosis. Eighteen (64%) patients were treated with chronic suppressive azole therapy for a median length of 36\u00a0months (range 15\u201090). One patient had an adverse drug interaction requiring azole discontinuation. There were no episodes of azole\u2010related hepatotoxicity, toxicity from antirejection medication, or <jats:styled-content style=\"fixed-case\">EFI<\/jats:styled-content> reactivation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Chronic suppressive azole therapy was safe and effective in preventing reactivation of <jats:styled-content style=\"fixed-case\">EFI<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content> recipients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12963","type":"journal-article","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T13:09:08Z","timestamp":1530796148000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Safety and efficacy of chronic suppressive azole therapy for endemic fungal infections in solid organ transplant recipients"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8328-4867","authenticated-orcid":false,"given":"Sonya A.","family":"Trinh","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Northwestern University Feinberg School of Medicine  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6301-0121","authenticated-orcid":false,"given":"Ignacio A.","family":"Echenique","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Cleveland Clinic Florida  Weston Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhir","family":"Penugonda","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Northwestern University Feinberg School of Medicine  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Angarone","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Northwestern University Feinberg School of Medicine  Chicago 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