{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T09:02:43Z","timestamp":1777021363169,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T00:00:00Z","timestamp":1532044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pre\u2010transplant cytomegalovirus (<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>) serostatus has been associated with lung transplant patient survival. We retrospectively analyzed the relationship between pre\u2010transplant donor\/recipient <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> serostatus and long\u2010term mortality in a cohort of lung transplant recipients at our center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Adult (Age &gt;17\u00a0years) lung recipients transplanted between July 1985\u2010December 2015 were analyzed. Variables included age, sex, pre\u2010transplant donor (D)\/recipient (R) serostatus [D\u2212\/R\u2212, D\u2212\/R+, D+\/R+, D+\/R\u2212], <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> infection within 2\u00a0years of transplant and transplant eras divided by changes in <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> prevention strategies: Era 1 (pre\u2010ganciclovir, July 1985\u2010April 1998), Era 2 (oral ganciclovir, May 1998\u2010December 2004), Era 3 (valganciclovir, January 2005\u2010December 2015). Survival analysis and Cox regression were performed at 10\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 652 lung recipients were analyzed. Twenty percent were <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> mismatched pre\u2010transplant and 45% had <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> infection within 2\u00a0years post\u2010transplant. Survival at 10\u00a0years appeared worse in D+ transplants (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.027). D\u2212\/R\u2212 lungs did not have significantly different survival across eras (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.76), but survival of D\u2212\/R+, D+\/R+, D+\/R\u2212 lungs improved (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Cox regression revealed that transplantation in the valganciclovir era reduced risk of death in lung transplants by an estimated 52% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) compared to transplantation in the pre\u2010ganciclovir era after controlling for age at transplant, D\/R <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> serostatus and <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> infection. Age at transplant and <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> infection were also significant predictors of mortality in lung transplants (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001 and 0.033 respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our review of the impact of <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> managed differently across eras suggests in lung transplantation there is no independent influence of D\/R <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> serostatus on 10\u2010year survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12964","type":"journal-article","created":{"date-parts":[[2018,7,7]],"date-time":"2018-07-07T07:53:26Z","timestamp":1530950006000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Impact of donor and recipient cytomegalovirus serology on long\u2010term survival of lung transplant recipients"],"prefix":"10.1111","volume":"20","author":[{"given":"Curtis","family":"Mabilangan","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine University of Alberta  Edmonton AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jutta","family":"Preiksaitis","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine University of Alberta  Edmonton AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0161-1749","authenticated-orcid":false,"given":"Carlos","family":"Cervera","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine University of Alberta  Edmonton AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the University of Alberta Cardiothoracic Transplant 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