{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:33:29Z","timestamp":1761744809086,"version":"3.41.2"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T00:00:00Z","timestamp":1535587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["KL2TR002374","UL1TR000427"],"award-info":[{"award-number":["KL2TR002374","UL1TR000427"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Polyomavirus\u2010associated nephropathy is associated with high risk of kidney allograft loss. Whether the cause of native end\u2010stage renal disease influences the risk of <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> infection is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective, single\u2010center study of 2741 adult kidney transplant recipients between 1994 and 2014 was performed. Recipients had end\u2010stage renal disease due to polycystic kidney disease (<jats:styled-content style=\"fixed-case\">PKD<\/jats:styled-content>, n\u00a0=\u00a0549), diabetes mellitus (<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>, n\u00a0=\u00a0947), hypertension (<jats:styled-content style=\"fixed-case\">HTN<\/jats:styled-content>, n\u00a0=\u00a0442), or glomerulonephritis (<jats:styled-content style=\"fixed-case\">GN<\/jats:styled-content>, n\u00a0=\u00a0803).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 327 recipients (12%) developed post\u2010transplant <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> viremia over a median follow\u2010up time of 5\u00a0years. The incidence rate of <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> viremia was lowest in patients with <jats:styled-content style=\"fixed-case\">PKD<\/jats:styled-content> (1.46 per 100 person\u2010years) compared to other causes of <jats:styled-content style=\"fixed-case\">ESRD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>\u00a0=\u00a02.06, <jats:styled-content style=\"fixed-case\">HTN<\/jats:styled-content>\u00a0=\u00a02.65, and <jats:styled-content style=\"fixed-case\">GN<\/jats:styled-content>\u00a0=\u00a02.01 per 100 person\u2010years). A diagnosis of <jats:styled-content style=\"fixed-case\">PKD<\/jats:styled-content> was associated with a lower risk of post\u2010transplant <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> viremia (adjusted <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>)\u00a0=\u00a00.67 (0.48\u20100.95), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02). <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> nephropathy was significantly less common in patients with <jats:styled-content style=\"fixed-case\">PKD<\/jats:styled-content> (0.21 per 100 person\u2010years) compared to those with <jats:styled-content style=\"fixed-case\">HTN<\/jats:styled-content> (0.80 per 100 person\u2010years, <jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.001). Among patients with <jats:styled-content style=\"fixed-case\">PKD<\/jats:styled-content>, the risk of <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> viremia was lower in patients with nephrectomy, compared to those without nephrectomy (adjusted <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>)\u00a0=\u00a00.42 (0.19\u20100.92), <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ESRD<\/jats:styled-content> due to <jats:styled-content style=\"fixed-case\">PKD<\/jats:styled-content> is associated with a lower risk of post\u2010transplant <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> infection. The renal tubular epithelial cells in <jats:styled-content style=\"fixed-case\">PKD<\/jats:styled-content> are unique; they are in a proliferative but non\u2010differentiated state. Whether this characteristic of renal tubular epithelial cells alters the <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> viral reservoir or replication in <jats:styled-content style=\"fixed-case\">PKD<\/jats:styled-content> patients warrants further study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12974","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T16:25:25Z","timestamp":1534177525000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Kidney transplant recipients with polycystic kidney disease have a lower risk of post\u2010transplant <scp>BK<\/scp> infection than those with end\u2010stage renal disease due to other causes"],"prefix":"10.1111","volume":"20","author":[{"given":"Callie","family":"Plafkin","sequence":"first","affiliation":[{"name":"Department of Medicine University of Wisconsin\u2010Madison School of Medicine and Public Health  Madison Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8855-3421","authenticated-orcid":false,"given":"Tripti","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine University of Wisconsin\u2010Madison  Madison Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0876-0069","authenticated-orcid":false,"given":"Brad C.","family":"Astor","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Wisconsin\u2010Madison School of Medicine and Public Health  Madison Wisconsin"},{"name":"Department of Population Health Sciences University of Wisconsin\u2010Madison School of Medicine and Public Health  Madison Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1667-7465","authenticated-orcid":false,"given":"Sandesh","family":"Parajuli","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine University of Wisconsin\u2010Madison  Madison Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gauri","family":"Bhutani","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine University of Wisconsin\u2010Madison  Madison Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasia","family":"Safdar","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease Department of Medicine University of Wisconsin\u2010Madison  Madison Wisconsin"},{"name":"Division of Infectious Disease Department of Medicine William S. 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