{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:39:56Z","timestamp":1784194796183,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T00:00:00Z","timestamp":1535673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cryptococcosis is a common invasive fungal infection (<jats:styled-content style=\"fixed-case\">IFI<\/jats:styled-content>) in solid organ transplant (<jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content>) recipients. Little is known about cryptococcosis in lung transplant (<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>x) recipients despite having one of the highest risks of infection. The aim of this study was to describe demographic and clinical features of cryptococcal infection in <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>x recipients. We performed a retrospective, observational study of cryptococcal infection in <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>x recipients at The Alfred Hospital in Melbourne, Australia, from 2012 to 2017. A total of 11 cases were identified. Seven patients (64%) were male and the median age was 54.7\u00a0years (range 34\u201069\u00a0years). Diagnosis occurred at a median of 233\u00a0days (range 1\u20103650\u00a0days) post\u2010transplant. Nine patients (82%) had isolated pulmonary infection of whom 7 (78%) were asymptomatic. All were treated with oral antifungal therapy and 1 required surgical resection of infected lung. Two patients (18%) had disseminated infection; 1 with pulmonary and central nervous system (<jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>) infection and 1 with isolated <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> infection. Both patients presented with headache and brain imaging demonstrated cerebral edema, myelinosis, and leptomeningeal enhancement. One of these patients died. This study highlights the fact that cryptococcal infection should remain a consideration in asymptomatic <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>x recipients, especially in the presence of non\u2010specific nodules on chest imaging, and that the presence of headache in these patients requires urgent investigation for <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> infection.<\/jats:p>","DOI":"10.1111\/tid.12976","type":"journal-article","created":{"date-parts":[[2018,8,18]],"date-time":"2018-08-18T11:48:51Z","timestamp":1534592931000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cryptococcal infection in lung transplant recipients: A 5\u2010year retrospective review at an Australian transplant 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