{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T12:19:08Z","timestamp":1773058748007,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T00:00:00Z","timestamp":1535932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2018,12]]},"abstract":"Abstract<\/jats:title>Allogeneic hematopoietic cell transplant (HCT<\/jats:styled-content>) recipients are at risk for herpes simplex virus (HSV<\/jats:styled-content>) and varicella\u2010zoster virus (VZV<\/jats:styled-content>) infections. Routine prophylaxis with acyclovir is recommended during periods of immunosuppression. Brincidofovir (BCV<\/jats:styled-content>, CMX<\/jats:styled-content>001), a lipid conjugate of cidofovir, has shown in vitro activity against HSV<\/jats:styled-content>\/VZV<\/jats:styled-content>, but has not been formally studied for HSV<\/jats:styled-content>\/VZV<\/jats:styled-content> prophylaxis. We report our clinical experience of BCV<\/jats:styled-content> for HSV<\/jats:styled-content>\/VZV<\/jats:styled-content> prophylaxis in HCT<\/jats:styled-content> recipients. This was a retrospective review of 30 hematopoietic cell transplant (HCT<\/jats:styled-content>) recipients between 8\/2010 and 8\/2015 who received BCV<\/jats:styled-content> doses not exceeding 200\u00a0mg\/week for adults\/adolescents and 4\u00a0mg\/kg\/week for pediatric (<12\u00a0years) patients, for \u226514\u00a0days BCV<\/jats:styled-content> without concomitant acyclovir under clinical trials or single patient use. HSV<\/jats:styled-content>\/VZV<\/jats:styled-content> cases during BCV<\/jats:styled-content> treatment were confirmed by viral culture or PCR<\/jats:styled-content> and clinical symptoms. Of 30 patients who met the inclusion criteria, 27 (90%) patients were adults and 22 (73%) patients received T\u2010cell depleted HCT<\/jats:styled-content>. The most common indications for BCV<\/jats:styled-content> were cytomegalovirus in 12 patients (40%) and adenovirus in 11 patients (37%). One patient was treated for acyclovir\u2010resistant HSV<\/jats:styled-content> and one for disseminated VZV<\/jats:styled-content>. There were two breakthrough cases of HSV<\/jats:styled-content> infection during 2170 patient\u2010days. There were no cases of breakthrough VZV<\/jats:styled-content> infection. The overall rate of breakthrough HSV<\/jats:styled-content> infection was 1.0 per 1000 patient\u2010days, without any breakthrough VZV<\/jats:styled-content> infections. Our study provides the only available\u2014albeit limited\u2014evidence on the potential efficacy of BCV<\/jats:styled-content> for HSV<\/jats:styled-content>\/VZV<\/jats:styled-content> prophylaxis in HCT<\/jats:styled-content> patients. Additional studies are needed to further assess the efficacy and safety of BCV<\/jats:styled-content> in the setting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12977","type":"journal-article","created":{"date-parts":[[2018,8,18]],"date-time":"2018-08-18T11:38:31Z","timestamp":1534592311000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Efficacy of brincidofovir as prophylaxis against HSV<\/scp> and VZV<\/scp> in hematopoietic cell transplant recipients"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2997-0217","authenticated-orcid":false,"given":"Yeon Joo","family":"Lee","sequence":"first","affiliation":[{"name":"Infectious Diseases Service Department of Medicine Memorial Sloan Kettering Cancer Center New York New York"},{"name":"Weill Cornell Medical College Cornell University New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dionysios","family":"Neofytos","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service Department of Medicine Memorial Sloan Kettering Cancer Center New York New York"},{"name":"Division of Infectious Diseases University Hospital of Geneva Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service Department of Medicine Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie","family":"Cheteyan","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service Department of Medicine Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao\u2010Ting","family":"Huang","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service Department of Medicine Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esperanza B.","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical College Cornell University New York New York"},{"name":"Adult Bone Marrow Transplantation Service Department of Medicine Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann A.","family":"Jakubowski","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical College Cornell University New York New York"},{"name":"Adult Bone Marrow Transplantation Service Department of Medicine Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genovefa A.","family":"Papanicolaou","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service Department of Medicine Memorial Sloan Kettering Cancer Center New York New York"},{"name":"Weill Cornell Medical College Cornell University New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2009.254"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2014.948847"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1303688"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2016.12.621"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12582"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.07.010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703354"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/518938"},{"key":"e_1_2_8_10_1","first-page":"1085","article-title":"Varicella 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