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We included 479 allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> recipients with 10 invasive candidiasis (<jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content>) and 31 probable\/proven invasive mold disease (<jats:styled-content style=\"fixed-case\">IMD<\/jats:styled-content>) from the Swiss Transplant Cohort Study from 01.2009 to 08.2013. Overall cumulative incidence was 2.3% for <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content> and 8.5% for probable\/proven <jats:styled-content style=\"fixed-case\">IMI<\/jats:styled-content>: 6% for invasive aspergillosis (<jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>) and 2.5% for non\u2010<jats:italic>Aspergillus<\/jats:italic><jats:styled-content style=\"fixed-case\">IMI<\/jats:styled-content>. Among 41 <jats:styled-content style=\"fixed-case\">IFD<\/jats:styled-content>, 46% <jats:styled-content style=\"fixed-case\">IFD<\/jats:styled-content> were breakthrough, with an overall incidence of 4.6%, more frequently caused by other\u2010than\u2010<jats:italic>Aspergillus fumigatus<\/jats:italic> molds than primary <jats:styled-content style=\"fixed-case\">IFD<\/jats:styled-content> (47.6% (10\/21) vs 13% (3\/23), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). Twelve\u2010week mortality among patients with <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content> was 20% and 58.6% for probable\/proven <jats:styled-content style=\"fixed-case\">IMD<\/jats:styled-content> (60% <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> and 54.6% non\u2010<jats:italic>Aspergillus<\/jats:italic>). Our results reveal that breakthrough <jats:styled-content style=\"fixed-case\">IFD<\/jats:styled-content> represent a marked burden of probable\/proven <jats:styled-content style=\"fixed-case\">IFD<\/jats:styled-content> postallogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> and mortality remains above 50% in patients with probable\/proven <jats:styled-content style=\"fixed-case\">IMD<\/jats:styled-content>, underscoring the ongoing challenges to prevent and treat <jats:styled-content style=\"fixed-case\">IFD<\/jats:styled-content> in these patients.<\/jats:p>","DOI":"10.1111\/tid.12981","type":"journal-article","created":{"date-parts":[[2018,8,25]],"date-time":"2018-08-25T14:43:46Z","timestamp":1535208226000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Incidence and outcome of invasive fungal diseases after allogeneic hematopoietic stem cell transplantation: A Swiss transplant 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