{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:59:02Z","timestamp":1790837942066,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T00:00:00Z","timestamp":1537315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2018,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Descriptive data on Pneumocystis jirovecii<\/jats:italic> pneumonia (PJP<\/jats:styled-content>) in solid organ transplant recipients (SOT<\/jats:styled-content>r) in the era of routine Pneumocystis<\/jats:italic>\u2010prophylaxis are lacking.<\/jats:p><\/jats:sec>Methods<\/jats:title>All adult SOT<\/jats:styled-content>r between 2008 and 2016 were included. PJP<\/jats:styled-content> was diagnosed based on consensus guidelines. Early\u2010onset PJP<\/jats:styled-content> was defined as PJP<\/jats:styled-content> within the first\u2010year\u2010post\u2010transplant.<\/jats:p><\/jats:sec>Results<\/jats:title>41\/2842 SOT<\/jats:styled-content>r (1.4%) developed PJP<\/jats:styled-content> (incidence rate: 0.01\/1000 person\u2010days) at a mean of 493\u2010days post\u2010transplant: 21 (51.2%) early vs 20 (48.8%) late\u2010onset PJP<\/jats:styled-content>. 2465 (86.7%) SOT<\/jats:styled-content>r received Pneumocystis<\/jats:italic>\u2010prophylaxis for a mean 316 days. PJP<\/jats:styled-content> incidence was 0.001% and 0.003% (log\u2010rank < 0.001) in SOT<\/jats:styled-content>r with and without Pneumocystis<\/jats:italic>\u2010prophylaxis, respectively. PJP<\/jats:styled-content> was an early event in 10\/12 (83.3%) SOT<\/jats:styled-content>r who did not receive Pneumocystis<\/jats:italic>\u2010prophylaxis and developed PJP<\/jats:styled-content>, compared to those patients who received prophylaxis (11\/29, 37.9%; P<\/jats:italic>\u2010value: 0.008). Among late\u2010onset PJP<\/jats:styled-content> patients, most cases (13\/20, 65%) were observed during the 2nd year post\u2010transplant. Age \u226565 years (OR<\/jats:styled-content>: 2.4, P<\/jats:italic>\u2010value: 0.03) and CMV<\/jats:styled-content> infection during the first 6 months post\u2010SOT<\/jats:styled-content> (OR<\/jats:styled-content>: 2.5, P<\/jats:italic>\u2010value: 0.006) were significant PJP<\/jats:styled-content> predictors, while Pneumocystis<\/jats:italic>\u2010prophylaxis was protective for PJP<\/jats:styled-content> (OR<\/jats:styled-content>: 0.3, P<\/jats:italic>\u2010value: 0.006) in the overall population. Most patients (35, 85.4%) were treated with trimethoprim\u2010sulfamethoxazole for a mean 20.6 days. 1\u2010year mortality was 14.6%.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In the Pneumocystis<\/jats:italic>\u2010prophylaxis\u2010era, PJP<\/jats:styled-content> remains a rare post\u2010transplant complication. Most cases occurred post\u2010PJP<\/jats:styled-content>\u2010prophylaxis\u2010discontinuation, particularly during the second\u2010year\u2010post\u2010transplant. Additional research may help identify indications for Pneumocystis<\/jats:italic>\u2010prophylaxis prolongation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12984","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T06:37:01Z","timestamp":1535611021000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Pneumocystis jirovecii<\/i> pneumonia in solid organ transplant recipients: a descriptive analysis for the Swiss Transplant Cohort"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6970-2869","authenticated-orcid":false,"given":"Dionysios","family":"Neofytos","sequence":"first","affiliation":[{"name":"Transplant Infectious Diseases Unit University Hospitals of Geneva and Faculty of Medicine Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedric","family":"Hirzel","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Boely","sequence":"additional","affiliation":[{"name":"Transplant Infectious Diseases Unit University Hospitals of Geneva and Faculty of Medicine Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanh","family":"Lecompte","sequence":"additional","affiliation":[{"name":"Transplant Infectious Diseases Unit University Hospitals of Geneva and Faculty of Medicine Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2642-419X","authenticated-orcid":false,"given":"Nina","family":"Khanna","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology University and University Hospital of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas J.","family":"Mueller","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology University Hospital of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Boggian","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology Cantonal Hospital St Gallen St Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexia","family":"Cusini","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7607-0943","authenticated-orcid":false,"given":"Oriol","family":"Manuel","sequence":"additional","affiliation":[{"name":"Service of Infectious Diseases and Transplantation Center University Hospital of Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"van Delden","sequence":"additional","affiliation":[{"name":"Transplant Infectious Diseases Unit University Hospitals of Geneva and Faculty of Medicine Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Swiss Transplant Cohort Study","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2014.07.010"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof1030293"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12947"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12119"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00095811"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2011.00645.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2012.00740.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/323129"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2011.00692.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03143.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.377"},{"issue":"4","key":"e_1_2_6_13_1","first-page":"36","article-title":"European best practice guidelines for renal transplantation. 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