{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T23:30:21Z","timestamp":1773099021625,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:00:00Z","timestamp":1537488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patient outcomes post\u2010lung transplant remain inferior to other types of solid organ transplantation. We investigated whether the presence of potentially pathogenic bacteria (<jats:styled-content style=\"fixed-case\">PPB<\/jats:styled-content>) in donor lung bronchial cultures was associated with adverse outcomes postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients who underwent lung transplantation between August 2015 and April 2017 at the University of Kentucky Medical Center were retrospectively reviewed. Retransplants, patients with bronchiectasis (including cystic fibrosis), and individuals who received organs from donation after cardiac death (<jats:styled-content style=\"fixed-case\">DCD<\/jats:styled-content>) donors were excluded. The remaining subjects were separated into two groups: individuals whose donor bronchial cultures grew <jats:styled-content style=\"fixed-case\">PPB<\/jats:styled-content>, and those whose cultures either returned negative for <jats:styled-content style=\"fixed-case\">PPB<\/jats:styled-content> or were sterile. 30\u2010day mortality rates as well as the incidence of grade 3 primary graft dysfunction (<jats:styled-content style=\"fixed-case\">PGD<\/jats:styled-content>) and acute kidney injury (<jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>) at both 24 and 72\u00a0hours post\u2010transplant were calculated. The duration of mechanical ventilation postoperatively was also recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty two subjects comprised the study population. 20 patients (63%) had growth of <jats:styled-content style=\"fixed-case\">PPB<\/jats:styled-content> on donor cultures, while 12 (37%) did not. Patients with <jats:styled-content style=\"fixed-case\">PPB<\/jats:styled-content> had a significantly greater number of days on the ventilator postoperatively compared to those with no <jats:styled-content style=\"fixed-case\">PPB<\/jats:styled-content> (mean\u00a0=\u00a011.3 and median\u00a0=\u00a05.0 vs mean\u00a0=\u00a05.8 and median\u00a0=\u00a03.0, respectively, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0232). Subsequent regression analysis revealed this association to not be influenced by recipient lung allocation score (<jats:styled-content style=\"fixed-case\">LAS<\/jats:styled-content>), donor age, donor smoking history, recipient mean pulmonary artery pressure (<jats:styled-content style=\"fixed-case\">mPAP<\/jats:styled-content>) value, and\/or use of cardiopulmonary bypass at the time of transplantation. Neither 30\u2010day survival nor incidence of Grade 3 <jats:styled-content style=\"fixed-case\">PGD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> at 24 or 72\u00a0hours post\u2010transplant differed between the two groups (<jats:italic>P\u00a0<\/jats:italic>&gt;<jats:italic>\u00a0<\/jats:italic>0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The recovery of <jats:styled-content style=\"fixed-case\">PPB<\/jats:styled-content> in donor lung cultures was associated with a longer duration of mechanical ventilation postoperatively in lung transplant recipients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.12986","type":"journal-article","created":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T14:09:49Z","timestamp":1535810989000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Impact of donor lung pathogenic bacteria on patient outcomes in the immediate post\u2010transplant period"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5726-3723","authenticated-orcid":false,"given":"Omar","family":"Ahmad","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases University of Kentucky Lexington Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis E.","family":"Shafii","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery University of Kentucky Lexington Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Mannino","sequence":"additional","affiliation":[{"name":"Department of Preventative Medicine and Environmental Health University of Kentucky Lexington Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radmila","family":"Choate","sequence":"additional","affiliation":[{"name":"Department of Preventative Medicine and Environmental Health University of Kentucky Lexington Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maher A.","family":"Baz","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery University of Kentucky Lexington Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.08.014"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201210-1865OC"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200608-1079OC"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2007.07.018"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.00867.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.4.1222"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.7.813"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201304-0691OC"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.22.2859"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(03)00454-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2011.00701.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2006.12.009"},{"issue":"5","key":"e_1_2_6_14_1","first-page":"502","article-title":"Influence of the donor lung on development of early infections in lung transplant recipients","volume":"9","author":"Zenati M","year":"1990","journal-title":"J Heart Transplant"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/S0022-5223(19)33702-X","article-title":"The donor lung: infectious and pathologic factors affecting outcome in lung transplantation","volume":"106","author":"Low DE","year":"1993","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.06.026"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(01)00415-6"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(95)70222-9"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.104.5.1412"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-991527"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-991520"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1547347"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.112.4.924"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.08.004"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mot.0000127632.16121.a9"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2011.10.001"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc1450"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-016-0140-x"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.12986","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.12986","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T02:25:45Z","timestamp":1694744745000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.12986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,21]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1111\/tid.12986"],"URL":"https:\/\/doi.org\/10.1111\/tid.12986","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,21]]},"assertion":[{"value":"2018-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12986"}}