{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:33:26Z","timestamp":1761744806044,"version":"3.41.2"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,28]],"date-time":"2018-10-28T00:00:00Z","timestamp":1540684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Strongyloides stercoralis<\/jats:italic> is an intestinal helminth which in humans can cause asymptomatic chronic infection maintained for decades through its auto\u2010infective cycle. During solid organ transplantation, recipients may unintentionally receive an organ infected with strongyloides. This is a very rare complication but may have deadly outcome if not detected. We hereby report two transplant recipients whom developed <jats:italic>Strongyloides<\/jats:italic> hyperinfection syndrome after organ transplantation from the same deceased donor. Recipient 1 was kidney transplanted and presented at day 65 post engraftment with diarrhea and subsequent septicemia and gastric retention. Larvae were detected in gastric aspirate. Recipient 2 was simultaneously kidney and pancreas transplanted and presented at day 90 post engraftment also with gastric retention and septicemia. Larvae were demonstrated on duodenal biopsy and stool sample. The clinical course was complicated with severe duodenal bleedings, gastric retention, meningitis, and prolonged hospitalization. Retrospective testing of pre\u2010transplant donor serum was positive for <jats:italic>Strongyloides stercoralis <\/jats:italic>antibodies. As a result of disease severity and gastric retention albenazole was administered via a jejunal tube and ivermectin subcutaneously in both recipients. <jats:italic>S\u00a0stercoralis<\/jats:italic> was successfully eradicated and the transplants ended up with unaffected graft function. Following these two cases, we started systematic screening of all deceased donors for serum <jats:italic>Strongyloides<\/jats:italic> IgG in October 2016. After having screened 150 utilized donors one tested positive for <jats:italic>Strongyloides<\/jats:italic>, which initiated prophylactic ivermectin treatment to organ recipients. No symptoms or disease developed. Our center will continue to screen all donors as prophylactic treatment may avert this potentially lethal complication in cases of donor\u2010derived <jats:italic>Strongyloides<\/jats:italic> infection.<\/jats:p>","DOI":"10.1111\/tid.13008","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T09:45:56Z","timestamp":1538991956000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Donor\u2010derived strongyloidiasis after organ transplantation in Norway"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8144-0395","authenticated-orcid":false,"given":"Espen","family":"Nordheim","sequence":"first","affiliation":[{"name":"Department of Transplantation Medicine Oslo University Hospital \u2013 Rikshospitalet Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Olafsson Storr\u00f8","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine Oslo University Hospital \u2013 Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ane Kristine","family":"Natvik","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Oslo University Hospital \u2013 Ullev\u00e5l Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grete","family":"Birkeland Kro","sequence":"additional","affiliation":[{"name":"Department of Microbiology Oslo University Hospital \u2013 Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karsten","family":"Midtvedt","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine Oslo University Hospital \u2013 Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Varberg Reis\u00e6ter","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine Oslo University Hospital \u2013 Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten","family":"Hagness","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine Oslo University Hospital \u2013 Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00f8rre","family":"Fevang","sequence":"additional","affiliation":[{"name":"Section of Clinical Immunology and Infectious Diseases Oslo University Hospital Oslo Norway"},{"name":"Research Institute of Internal Medicine Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank O.","family":"Pettersen","sequence":"additional","affiliation":[{"name":"Regional Advisory Unit for Imported and Tropical Diseases, Department of Infectious Diseases Oslo University Hospital \u2013 Ullev\u00e5l Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002288"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2008.01.020"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2009.00375.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2003.06.008"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2008.00350.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2007.00256.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12120"},{"key":"e_1_2_6_9_1","unstructured":"FrimanGG JalankoH LindtM MoserC \u00d8yenO.Guidelines for prevention of transmission of infectious diseases from organ donors to recipients. 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