{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:13:52Z","timestamp":1793060032532,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T00:00:00Z","timestamp":1544745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hepatitis E virus (HEV) infection can lead to chronic hepatitis in solid organ transplant recipients. To investigate whether HEV infection influences outcomes following kidney transplantation, we examined the prevalence of HEV infection and clinical characteristics of kidney transplant recipients in our hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our cross\u2010sectional study included 184 kidney transplant recipients. Blood samples were obtained from all patients to detect anti\u2010HEV immunoglobulin (Ig)A, IgM, and IgG by enzyme\u2010linked immunosorbent assay and HEV RNA by reverse transcription polymerase chain reaction. Clinical data were collected from medical charts for all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of anti\u2010HEV IgG was 8\/184 (4.3%). Anti\u2010HEV IgA, anti\u2010HEV IgM, and HEV RNA were not detected in any patients. Compared to their anti\u2010HEV IgG\u2010negative counterparts, anti\u2010HEV IgG\u2010positive patients were significantly older at the time of transplantation, and they were more likely to receive kidneys from deceased donors. No significant differences in other characteristics such as the prevalence of primary cause of end\u2010stage renal disease, blood transfusion, and immunosuppressive therapy use; liver and renal function; and the frequencies of hepatitis B and hepatitis C virus infection were observed according to the patients' anti\u2010HEV IgG status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HEV infection had no significant influence on the outcomes of kidney transplantation at our institution. However, HEV infection should be recognized in kidney transplant recipients similarly as hepatitis B and hepatitis C virus infection in cases of liver dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13033","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T19:02:31Z","timestamp":1543345351000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prevalence and characteristics of hepatitis E virus infection in kidney transplant recipients: A single\u2010center experience in Japan"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3987-4832","authenticated-orcid":false,"given":"Koji","family":"Nanmoku","sequence":"first","affiliation":[{"name":"Surgical Branch, Institute of Kidney Diseases Jichi Medical University Hospital Shimotsuke 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