{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:46:25Z","timestamp":1784641585841,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T00:00:00Z","timestamp":1553126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We studied cytokine profiles in BAL of LTRs with Aspergillus spp colonization who did not progress to IPA in the absence of antifungal prophylaxis. This was a retrospective, single center case\u2010control study. BAL samples were analyzed for cytokines. Patients with <jats:italic>Aspergillus<\/jats:italic> spp in BAL who did not receive prophylaxis and did not develop IPA were compared to LTRs with <jats:italic>Aspergillus<\/jats:italic> spp that received prophylaxis, LTRs with IPA and controls. Twenty\u2010one patients with <jats:italic>Aspergillus<\/jats:italic> colonization who did not develop IPA, seven patients with suspected IPA who received prophylaxis, 4 IPA and 19 controls were included. IPA group had significantly higher levels (median [IQR]) of MIP\u20101 beta compared to the Suspected IPA group (5 vs 5 <jats:italic>P<\/jats:italic>: 0.03). The Suspected IPA group had significantly higher levels of IL\u201012 (11.38 vs 1 <jats:italic>P<\/jats:italic>: 0.0001), IL\u20101 RA (86.11 vs 23.98 <jats:italic>P<\/jats:italic>: 0.0118), IP\u201010 (22.47 vs 0.86 <jats:italic>P<\/jats:italic>: 0.0151), HGF (40.92 vs 16.82 <jats:italic>P<\/jats:italic>: 0.0055), and MIG (169.62 vs 5 <jats:italic>P<\/jats:italic>: 0.0005) than Colonization group. We have identified a unique cytokine signature in patients with <jats:italic>Aspergillus<\/jats:italic> colonization that do not develop IPA. Our study forms basis for a larger study to use these cytokines profile to identify patients at a lower risk of developing IPA.<\/jats:p>","DOI":"10.1111\/tid.13060","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T20:11:51Z","timestamp":1550002311000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cytokine profile in lung transplant recipients with <i>Aspergillus<\/i> spp colonization"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5057-354X","authenticated-orcid":false,"given":"Sabina","family":"Herrera","sequence":"first","affiliation":[{"name":"Transplant Infectious Diseases, Toronto General Hospital, University Health Network University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wajiha","family":"Gohir","sequence":"additional","affiliation":[{"name":"Transplant Infectious Diseases, Toronto General Hospital, University Health Network University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1029-1812","authenticated-orcid":false,"given":"Farid","family":"Foroutan","sequence":"additional","affiliation":[{"name":"Ted Rogers Centre of Excellence in Heart Function, Peter Munk Cardiac Centre University Health Network Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Transplant Infectious Diseases, Toronto General Hospital, University Health Network University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Juvet","sequence":"additional","affiliation":[{"name":"Lung Transplant Program, Toronto General Hospital, University Health Network University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tereza","family":"Martinu","sequence":"additional","affiliation":[{"name":"Lung Transplant Program, Toronto General Hospital, University Health Network University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepali","family":"Kumar","sequence":"additional","affiliation":[{"name":"Transplant Infectious Diseases, Toronto General Hospital, University Health Network University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Humar","sequence":"additional","affiliation":[{"name":"Transplant Infectious Diseases, Toronto General Hospital, University Health Network University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1413-0968","authenticated-orcid":false,"given":"Coleman","family":"Rotstein","sequence":"additional","affiliation":[{"name":"Transplant Infectious Diseases, Toronto General Hospital, University Health Network University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaf","family":"Keshavjee","sequence":"additional","affiliation":[{"name":"Lung Transplant Program, Toronto General Hospital, University Health Network University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2693-8676","authenticated-orcid":false,"given":"Lianne G.","family":"Singer","sequence":"additional","affiliation":[{"name":"Lung Transplant Program, Toronto General Hospital, University Health Network University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahid","family":"Husain","sequence":"additional","affiliation":[{"name":"Transplant Infectious Diseases, Toronto General Hospital, University Health Network University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.09.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2006.12.009"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12691"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/651262"},{"issue":"3","key":"e_1_2_8_6_1","first-page":"269","article-title":"Epidemiological features of invasive mold infections among solid organ transplant recipients: PATH Alliance\u00ae registry analysis","volume":"55","author":"Husain S","year":"2017","journal-title":"Med Mycol"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2012.08.003"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.3.800"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.114.5.1321"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.112.5.1160"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-007-0376-3"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000743"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu337"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04904-7"},{"issue":"1","key":"e_1_2_8_15_1","doi-asserted-by":"crossref","first-page":"322","DOI":"10.4049\/jimmunol.158.1.322","article-title":"IL\u201010 exerts suppressive and enhancing effects on antifungal activity of mononuclear phagocytes against Aspergillus fumigatus","volume":"158","author":"Roilides E","year":"1997","journal-title":"J Immunol"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2018.02.006"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.01.701"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2007.10.017"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8097338"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1001"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1422"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840170618"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2006.10.061"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1086\/315142"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1086\/318077"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003936"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep26490"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06754.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12025"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02362"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1179\/joc.2011.23.1.5"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2016.10.010"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2009.03211.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2018.06.008"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14458"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezu395"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.13060","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13060","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.13060","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T10:19:25Z","timestamp":1694341165000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.13060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,21]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/tid.13060"],"URL":"https:\/\/doi.org\/10.1111\/tid.13060","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,21]]},"assertion":[{"value":"2019-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13060"}}