{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:04:43Z","timestamp":1761663883561,"version":"3.41.2"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T00:00:00Z","timestamp":1553644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Data on bloodstream infection (BSI) due to enteric organisms are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study (1\/2009\u20105\/2017) was aimed to evaluate the incidence of BSI episodes due to enteric organisms during the first 6\u00a0months after intestinal transplant (ITx). Differences between the first (2009\u20102012) and second period (2013\u20102017) were evaluated as they differed from each other in the perioperative fungal prophylaxis and immunosuppressive regimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010five adult patients were analyzed. Twenty\u2010eight (51%) patients developed a total of 51 episodes of BSI. Mean time from transplant to BSI was 85.5\u00a0\u00b1\u00a058.8\u00a0days. The most common organisms were <jats:italic>Klebsiella pneumoniae<\/jats:italic> (33%), <jats:italic>Enterococcus <\/jats:italic>spp (31%), and <jats:italic>Candida <\/jats:italic>spp (18%). Twenty\u2010three (45%) were multidrug resistant. The most common sources were gut translocation (35%), central line infection (20%), and intra\u2010abdominal abscess (14%). Biopsy\u2010proven rejection was associated with 16 (31%) of the BSI episodes. Patients during the first period were more likely to develop BSI (79% vs 41%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03). There were more episodes of rejection associated with BSI in the first period (45% vs 14%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03). The rate of reoperation into the abdominal cavity within 2\u00a0weeks after ITx was higher and the transplant hospital stay was longer among those who developed BSI (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04 for both).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Half of our patients developed BSI (typically during the first 3\u00a0months). Gut translocation was the most common source of BSI. Patients with rejection and\/or enteritis should be monitored closely for BSI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13064","type":"journal-article","created":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T15:19:25Z","timestamp":1552490365000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Bloodstream infection caused by enteric organisms during the first 6\u00a0months after intestinal transplant"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9626-0760","authenticated-orcid":false,"given":"Jacques","family":"Simkins","sequence":"first","affiliation":[{"name":"Department of Medicine\/Infectious Diseases University of Miami Miller School of Medicine Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose A.","family":"Morillas\u2010Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Infectious Diseases University of Miami Miller School of Medicine Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele I.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Infectious Diseases University of Miami Miller School of Medicine Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilian M.","family":"Abbo","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Infectious Diseases University of Miami Miller School of Medicine Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9584-5011","authenticated-orcid":false,"given":"Jose F.","family":"Camargo","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Infectious Diseases University of Miami Miller School of Medicine Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gennaro","family":"Selvaggi","sequence":"additional","affiliation":[{"name":"Department of Surgery\/Miami Transplant Institute University of Miami Miller School of Medicine Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago","family":"Beduschi","sequence":"additional","affiliation":[{"name":"Department of Surgery\/Miami Transplant Institute University of Miami Miller School of Medicine Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akin","family":"Tekin","sequence":"additional","affiliation":[{"name":"Department of Surgery\/Miami Transplant Institute University of Miami Miller School of Medicine Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Vianna","sequence":"additional","affiliation":[{"name":"Department of Surgery\/Miami Transplant Institute University of Miami Miller School of Medicine Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,27]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Organ Procurement and Transplantation Network.National Data.https:\/\/optn.transplant.hrsa.gov\/data\/view-data-reports\/national-data\/(Accessed on September 17 2018)."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13535"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318256f9c3"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2011.00683.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/674406"},{"key":"e_1_2_6_7_1","unstructured":"Centers for Disease Control and Prevention (CDC).CDC\/NHSN Surveillance Definitions for Specific Types of Infections; January 2018. Available athttp:\/\/www.cdc.gov\/nhsn\/pdfs\/pscmanual\/17pscnosinfdef_current.pdf(Accessed September 17 2018)."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2004.01.079"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2016.1139279"},{"key":"e_1_2_6_10_1","first-page":"2653","article-title":"Colonization and translocation of intestinal bacterial flora","volume":"28","author":"Wells CL","year":"1996","journal-title":"Transplant Proc"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199108000-00007"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200105270-00010"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(02)02681-7"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000157265.85388.a1"},{"key":"e_1_2_6_15_1","first-page":"277","article-title":"The antibiotic resistance crisis: part 1: causes and threats","volume":"40","author":"Lee Ventola C","year":"2015","journal-title":"P T"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2015.0220"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02304.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(90)90010-Y"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.13064","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13064","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.13064","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T10:18:07Z","timestamp":1694341087000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.13064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,27]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/tid.13064"],"URL":"https:\/\/doi.org\/10.1111\/tid.13064","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"type":"print","value":"1398-2273"},{"type":"electronic","value":"1399-3062"}],"subject":[],"published":{"date-parts":[[2019,3,27]]},"assertion":[{"value":"2018-09-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13064"}}