{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T09:03:49Z","timestamp":1772183029486,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T00:00:00Z","timestamp":1553212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lung transplantation has a high risk of cytomegalovirus (CMV) viremia and disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Valganciclovir was planned for 6\u00a0months in CMV recipient seropositive (R+) lung transplants (LTs) and given long\u2010term in D+R\u2212 LTs. CMV viremia was monitored regularly during and after prophylaxis in all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 137 LTs, 22 were D+R\u2212, 49 D+R+, 43 D\u2212R+, and 23 D\u2212R\u2212, with median follow up 4.1\u00a0years (IQR 2.1\u20106.2\u00a0years). CMV viremia at any time occurred in 44.5% of LTs. CMV viral load &gt;10<jats:sup>3<\/jats:sup>\u00a0c\/mL was uncommon (9\/77 episodes). CMV viremia occurred at median 665\u00a0days (IQR 271\u20101411\u00a0days), in 5.1% LTs &lt;6\u00a0months, 20.3% LTs 6\u201012\u00a0months, and 35.8% LTs &gt;12\u00a0months. CMV disease occurred in 6 (4.4%) LTs at an overall rate of 1.0 episode per 100 person\u2010years: two of these cases were organ\u2010specific disease, four were CMV syndrome. One case of ganciclovir\u2010resistant CMV was diagnosed. D+R+ and D+R\u2212 LTs had higher viremia rates than the D\u2212R+ group. No viremia occurred in D\u2212R\u2212 LTs. CMV viremia was not associated with age, gender, type of LT, indication for LT, acute rejection, bronchiolitis obliterans syndrome, or mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prophylaxis for 6\u00a0months in D+R+ and D\u2212R+, and past 12\u00a0months in D+R\u2212 LTs, with long\u2010term monitoring in all patients using a sensitive assay, and reinstitution of valganciclovir for low\u2010level viremia was effective at markedly reducing the incidence of CMV disease. CMV D\u2212R\u2212 LTs do not need routine CMV monitoring.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13069","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T02:42:21Z","timestamp":1552963341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cytomegalovirus viremia in lung transplantation during and after prophylaxis"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2557-170X","authenticated-orcid":false,"given":"Andrew","family":"Chang","sequence":"first","affiliation":[{"name":"Departments of Infectious Diseases and Microbiology Fiona Stanley Hospital and PathWest Laboratory Medicine WA Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Musk","sequence":"additional","affiliation":[{"name":"Advanced Lung Disease and Lung Transplantation Unit Fiona Stanley Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Lavender","sequence":"additional","affiliation":[{"name":"Advanced Lung Disease and Lung Transplantation Unit Fiona Stanley Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Wrobel","sequence":"additional","affiliation":[{"name":"Advanced Lung Disease and Lung Transplantation Unit Fiona Stanley Hospital Perth Western Australia Australia"},{"name":"The University of Notre Dame Fremantle Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meow\u2010Chong","family":"Yaw","sequence":"additional","affiliation":[{"name":"Advanced Lung Disease and Lung Transplantation Unit Fiona Stanley Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Advanced Lung Disease and Lung Transplantation Unit Fiona Stanley Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiji","family":"Chirayath","sequence":"additional","affiliation":[{"name":"Advanced Lung Disease and Lung Transplantation Unit Fiona Stanley Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0518-0421","authenticated-orcid":false,"given":"Peter","family":"Boan","sequence":"additional","affiliation":[{"name":"Departments of Infectious Diseases and Microbiology Fiona Stanley Hospital and PathWest Laboratory Medicine WA Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00505.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3947\/ic.2013.45.3.260"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00015-13"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-12-201006150-00003"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002191"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12103"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31822fa4b7"},{"key":"e_1_2_6_9_1","unstructured":"National Health and Medical Research Council Australian Research Council Australian Vice\u2010Chancellors\u2019 Committee.National statement on ethical conduct in human research 2007(updated May 2015). 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