{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T12:35:13Z","timestamp":1782995713779,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005845","name":"Hyogo College of Medicine","doi-asserted-by":"publisher","award":["2017"],"award-info":[{"award-number":["2017"]}],"id":[{"id":"10.13039\/501100005845","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Human leukocyte antigen (HLA) mismatch and the administration of immunosuppressive agents are considered risks for human herpesvirus 6 (HHV\u20106) reactivation after stem cell transplantation (SCT). However, the incidence of HHV\u20106 reactivation in HLA\u2010mismatched related SCT remains unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We monitored plasma HHV\u20106 DNA loads weekly using real\u2010time quantitative polymerase chain reaction for 5\u00a0weeks after SCT and compared serum IL\u20106 levels in HLA\u2010mismatched SCT groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with detection in all 11 umbilical cord blood transplantation (CBT) patients (100%), plasma HHV\u20106 DNA was detected in only 3 of 42 haplo\u2010SCT patients (7.1%) despite the use of methylprednisolone and antithymocyte globulin as graft\u2010vs\u2010host disease prophylaxis and a reduced\u2010intensity conditioning regimen, respectively. Correspondingly, serum IL\u20106 levels in haplo\u2010SCT patients were significantly lower than those in CBT patients. No HHV\u20106\u2010associated encephalitis developed in either groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Neither HLA disparity nor the use of methylprednisolone and antithymocyte globulin were risk factors for HHV\u20106 reactivation in our haplo\u2010SCT patients. Rather than increasing risk, the administration of immunosuppressive agents potentially prevented HHV\u20106 reactivation after haplo\u2010SCT by suppressing IL\u20106 production.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13073","type":"journal-article","created":{"date-parts":[[2019,3,16]],"date-time":"2019-03-16T05:21:53Z","timestamp":1552713713000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Low incidence of HHV\u20106 reactivation in haploidentical hematopoietic stem cell transplantation with corticosteroid as graft\u2010vs\u2010host disease prophylaxis compared with cord blood transplantation"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3348-7110","authenticated-orcid":false,"given":"Hiroya","family":"Tamaki","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine Hyogo College of Medicine Nishinomiya 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