{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T16:14:12Z","timestamp":1775837652086,"version":"3.50.1"},"reference-count":7,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T00:00:00Z","timestamp":1554249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Burkholderia cepacia<\/jats:italic> complex (Bcc) includes several phenotypically similar but genotypically distinct gram\u2010negative bacteria (GNB) that can colonize the respiratory tract of Cystic Fibrosis (CF) patients. Pathogens are difficult to treat due to intrinsic resistance to multiple antibiotics and are associated to a more rapid decline in lung function and to increased mortality, particularly after lung transplantation. For all these reasons, chronic infection by <jats:italic>Burkholderia (B) cenocepacia<\/jats:italic> is presently considered a relative or absolute contraindication in almost all lung transplant centres. We report the case of a young adult CF patient chronically colonized by <jats:italic>B multivorans<\/jats:italic> genomovar II, with diabetes and end\u2010stage renal disease treated with renal replacement therapy: a few months after lung transplantation, she developed post\u2010surgery <jats:italic>B multivorans<\/jats:italic> bacteremia and multiple brain abscesses. This severe infection did not improve despite multiple standard antibiotic regimen. The introduction of ceftazidime\u2010avibactam, a new \u03b2\u2010lactam\/ \u03b2\u2010lactamase inhibitor combination resulted in clinical recovery and in radiological and biochemical improvement.<\/jats:p>","DOI":"10.1111\/tid.13082","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T09:34:15Z","timestamp":1553074455000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Successful ceftazidime\u2010avibactam treatment of post\u2010surgery <i>Burkholderia multivorans<\/i> genomovar II bacteremia and brain abscesses in a young lung transplanted woman with cystic fibrosis"],"prefix":"10.1111","volume":"21","author":[{"given":"Valeria","family":"Dacc\u00f2","sequence":"first","affiliation":[{"name":"Cystic Fibrosis Center IRCCS Ca\u2019 Granda Foundation Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Claut","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Center IRCCS Ca\u2019 Granda Foundation Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Piconi","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease ASST Fatebenefratelli Sacco, University Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Castellazzi","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Center IRCCS Ca\u2019 Granda Foundation Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Garbarino","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Center IRCCS Ca\u2019 Granda Foundation Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Teri","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Microbiology Laboratory IRCCS Ca\u2019 Granda Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8975-695X","authenticated-orcid":false,"given":"Carla","family":"Colombo","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Center IRCCS Ca\u2019 Granda Foundation Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02186.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2016.07.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.7b00020"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1622"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky136"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky423"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00766-17"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13082","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.13082","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T10:19:15Z","timestamp":1694341155000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.13082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,3]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/tid.13082"],"URL":"https:\/\/doi.org\/10.1111\/tid.13082","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,3]]},"assertion":[{"value":"2018-11-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13082"}}