{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:09:59Z","timestamp":1791655799823,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T00:00:00Z","timestamp":1556755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Viral infections are a significant cause of morbidity and mortality in pediatric transplant populations. We analyzed the epidemiology of viral infections in pediatric hematopoietic stem cell transplant (HSCT) patients, including their incidence, associated risk factors, and outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective study from September 2011 to September 2015, blood, urine, and stool specimens were monitored weekly from transplantation to day 100 or after if clinically suspected, by use of real\u2010time polymerase chain reaction. Cytomegalovirus (CMV), Epstein\u2010Barr virus (EBV), BK polyomavirus (BKV), Herpes simplex virus\u20101,2, Varicella zoster virus, Human herpes virus\u20106,7, and Adenovirus infections were monitored. All children and adolescents who underwent HSCT received long\u2010term follow up in the regular outpatient clinics (range 2\u201048\u00a0months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 192 HSCTs (autologous\/allogeneic: 53\/139) were performed in 165 subjects (median age: 5.6 years). Viruses most commonly isolated were CMV (46.1%), BKV (25.9%) and EBV (22.6%) and were more frequent in allogeneic versus autologous transplants (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Almost all high\u2010risk allogeneic recipients developed EBV infections post\u2010HSCT. EBV\u2010PTLD was the only cause of death among those who developed viral disease. The factors significantly associated with the development of viral infections were recipient's advanced age, unrelated donor, mismatched graft and use of peripheral blood stem cells grafts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Viral infections were common among our pediatric recipients. Data suggest that monitoring of viral load may be significant to the prevention of viral disease. Particular demographic and transplantation characteristics were associated with the development of viral infections post\u2010HSCT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13095","type":"journal-article","created":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T02:29:22Z","timestamp":1555468162000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Epidemiology of viral infections among children undergoing hematopoietic stem cell transplant: \u0391 prospective single\u2010center study"],"prefix":"10.1111","volume":"21","author":[{"given":"Konstantinos","family":"Tsoumakas","sequence":"first","affiliation":[{"name":"Faculty of Nursing Pediatric Clinic, \"P &amp; A Kyriakou\" Children's Hospital, National and Kapodistrian University of Athens Athens Greece"},{"name":"Pediatric Research Laboratory, Faculty of Nursing National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4107-1086","authenticated-orcid":false,"given":"Konstantina","family":"Giamaiou","sequence":"additional","affiliation":[{"name":"Pediatric Research Laboratory, Faculty of Nursing National and Kapodistrian University of Athens Athens Greece"},{"name":"Stem cell Transplant Unit, \"Aghia Sophia\" Children's Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgenios","family":"Goussetis","sequence":"additional","affiliation":[{"name":"Stem cell Transplant Unit, \"Aghia Sophia\" Children's Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stelios","family":"Graphakos","sequence":"additional","affiliation":[{"name":"Stem cell Transplant Unit, \"Aghia Sophia\" Children's Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Kossyvakis","sequence":"additional","affiliation":[{"name":"Public Health Laboratories, Hellenic Pasteur Institute Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elina","family":"Horefti","sequence":"additional","affiliation":[{"name":"Public Health Laboratories, Hellenic Pasteur Institute Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Mentis","sequence":"additional","affiliation":[{"name":"Public Health Laboratories, Hellenic Pasteur Institute Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Elefsiniotis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Nursing Athens General and Oncology Hospital \"Agii Anargyri\", National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioanna D.","family":"Pavlopoulou","sequence":"additional","affiliation":[{"name":"Faculty of Nursing Pediatric Clinic, \"P &amp; 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