{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:09:35Z","timestamp":1791655775230,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T00:00:00Z","timestamp":1557532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Owing to the shortage of hematopoietic stem cells from matched sibling donors (MSD) and matched unrelated donors (MUD), the number of patients undergoing haploidentical allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT) has rapidly increased. Despite a comparable overall survival (OS) and leukemia\u2010free survival using this approach, some evidence suggests that haploidentical allo\u2010HSCT recipients have a higher incidence of cytomegalovirus (CMV) infection, though this has not been clearly established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study retrospectively compared the cumulative incidence of CMV DNAemia, 2\u2010year OS, and leukemia\u2010free survival rates in acute leukemia patients with MSD (n\u00a0=\u00a041), MUD (n\u00a0=\u00a018), and haploidentical donor allografts (n\u00a0=\u00a021).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cumulative incidences of CMV DNAemia at day 180 in the MSD, MUD, and haploidentical groups were 39.0, 55.6, and 85.7%, respectively (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.000). As less than 50% of patients in the MSD group were detected to have CMV DNAemia, the median time to CMV DNAemia detection in patients allografted with MSD could not be obtained. However, it was 42 and 29\u00a0days, respectively, for the MUD and haploidentical groups. Multivariate analysis revealed that haploidentical allo\u2010HSCT (MSD vs. haploidentical: HR: 0.26; 95% CI: 0.09\u20100.78; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.017) and age (HR: 1.03; 95% CI: 1.01\u20101.06; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.011) increased CMV infection. Finally, MSD, MUD, and haploidentical allo\u2010HSCT provided comparable 2\u2010year OS rates (52.1%, 65.5%, and 65.6%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.425) and 2\u2010year leukemia\u2010free survival rates (67.1%, 68.3%, and 80.7%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.837).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The CMV incidence was higher for haploidentical allo\u2010HSCT than for MSD and MUD allo\u2010HSCT; this could be explained by graft\u2010versus\u2010host disease prophylaxis by multiple immunosuppressants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13096","type":"journal-article","created":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T12:49:19Z","timestamp":1555764559000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Haploidentical allogeneic hematopoietic stem cell transplantation increases the risk of cytomegalovirus infection in adult patients with acute leukemia"],"prefix":"10.1111","volume":"21","author":[{"given":"Cheng\u2010Hsien","family":"Lin","sequence":"first","affiliation":[{"name":"Division of Hematology\/Medical Oncology, Department of Medicine Taichung Veterans General Hospital Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Jiun","family":"Su","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology, Department of Internal Medicine Chang Gung Memorial Hospital Linkou Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiann\u2010Yi","family":"Hsu","sequence":"additional","affiliation":[{"name":"Biostatistics Task Force Taichung Veterans General Hospital Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po\u2010Nan","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology, Department of Internal Medicine Chang Gung Memorial Hospital Linkou Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9744-0368","authenticated-orcid":false,"given":"Chieh\u2010Lin Jerry","family":"Teng","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Medical Oncology, Department of Medicine Taichung Veterans General Hospital Taichung Taiwan"},{"name":"Department of Life Science Tunghai University Taichung Taiwan"},{"name":"School of Medicine Chung Shan Medical University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1311707"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2017.34"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25231"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-04-639831"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.189258"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12629"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-11-679639"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-438408"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/339329"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.03.005"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2015.07.011"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.4274\/tjh.2016.0225"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-015-2423-y"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-304121"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-018-0172-y"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2013.10.003"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23998"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.149880"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.09.018"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706640"}],"container-title":["Transplant 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