{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T16:44:48Z","timestamp":1782751488679,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T00:00:00Z","timestamp":1564704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>BK polyomavirus reactivation can occur following allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT) and may lead to hemorrhagic cystitis (BKPyV\u2010HC). We hypothesized that development of BKPyV\u2010HC is associated with increased mortality post allo\u2010HSCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed data on 133 adult patients (\u226518\u00a0years old) who underwent allo\u2010HSCT from 2007 until 2014 at Hospital Israelita Albert Einstein in S\u00e3o Paulo, Brazil.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010six patients presented with BKPyV\u2010HC after a median time of 42\u00a0days, with a 1\u2010year cumulative incidence probability of 28.9% (95% CI 21.5%\u201036.7%). In a multivariate Cox model, risk factors for development of BKPyV\u2010HC included younger age, male sex, development of grade 2\u20104 acute graft\u2010versus\u2010host disease and recipients of umbilical cord blood grafts. Development of grade 3\u20104 BKPyV\u2010HC (but not grade 1\u20102) was associated with a decreased overall survival (OS) in a multivariate Cox model (hazard ratio [HR] 7.51, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) and an increased risk of TRM (HR 3.66, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). Grade 3\u20104 BKPyV\u2010HC was also associated with an increased risk of relapse that did not reach statistical significance (HR 3.01, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.07). Median overall survival (OS) post\u2010BKPyV\u2010HC was 4.7\u00a0months, and cidofovir had no impact on survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Development of BKPyV\u2010HC appears to be associated with decreased survival following allo\u2010HSCT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13101","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T14:14:25Z","timestamp":1557152065000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Severe hemorrhagic cystitis caused by the BK polyomavirus is associated with decreased survival post\u2010allogeneic hematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"21","author":[{"given":"Lucila Nassif","family":"Kerbauy","sequence":"first","affiliation":[{"name":"Department of Hematology and Stem Cell Transplantation, Centro de Hematologia e Oncologia Fam\u00edlia Dayan\u2010Daycoval 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