{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:36:30Z","timestamp":1761744990686,"version":"3.41.2"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T00:00:00Z","timestamp":1559606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009827","name":"Laura and John Arnold Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009827","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Between 2002 and 2013, the organs of 13 deceased donors with infectious encephalitis were transplanted, causing infections in 23 recipients. As a consequence, organs from donors showing symptoms of encephalitis (increased probability of infectious encephalitis (IPIE) organs) might be declined. We had previously characterized the risk of IPIE organs using data available to most transplant teams and not requiring special diagnostic tests. If the probability of infection is low, the benefits of a transplant from a donor with suspected infectious encephalitis might outweigh the risk and could be lifesaving for some transplant candidates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using organ transplant data and Cox Proportional Hazards models, we determined liver donor and recipient characteristics predictive of post\u2010transplant or waitlist survival and generated 5\u2010year survival probability curves. We also calculated expected waiting times for an organ offer based on transplant candidate characteristics. Using a limited set of actual cases of infectious encephalitis transmission via transplant, we estimated post\u2010transplant survival curves given an organ from an IPIE donor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>54% (1256) of patients registered from 2002\u20102006 who died or were removed from the waiting list because of deteriorated condition within 1\u00a0year could have had an at least marginal estimated benefit by accepting an IPIE liver with some probability of infection, with the odds increasing to 86% of patients if the probability of infection was low (5% or less). Additionally, 54% (1252) were removed from the waiting list prior to their estimated waiting time for a non\u2010IPIE liver and could have benefited from an IPIE liver.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Improved allocation and utilization of IPIE livers could be achieved by evaluating the patient\u2010specific trade\u2010offs between (a) accepting an IPIE liver and (b) remaining on the waitlist and accepting a non\u2010IPIE liver after the estimated waiting time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13115","type":"journal-article","created":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T19:49:34Z","timestamp":1558208974000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A mathematical model to describe survival among liver recipients from deceased donors with risk of transmitting infectious encephalitis pathogens"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0275-1807","authenticated-orcid":false,"given":"Hannah K.","family":"Smalley","sequence":"first","affiliation":[{"name":"H. Milton Stewart School of Industrial and Systems Engineering Georgia Institute of Technology Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nishi","family":"Anand","sequence":"additional","affiliation":[{"name":"H. Milton Stewart School of Industrial and Systems Engineering Georgia Institute of Technology Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dylan","family":"Buczek","sequence":"additional","affiliation":[{"name":"H. Milton Stewart School of Industrial and Systems Engineering Georgia Institute of Technology Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Buczek","sequence":"additional","affiliation":[{"name":"H. Milton Stewart School of Industrial and Systems Engineering Georgia Institute of Technology Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Lin","sequence":"additional","affiliation":[{"name":"H. Milton Stewart School of Industrial and Systems Engineering Georgia Institute of Technology Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanay","family":"Rajore","sequence":"additional","affiliation":[{"name":"H. Milton Stewart School of Industrial and Systems Engineering Georgia Institute of Technology Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muriel","family":"Wacker","sequence":"additional","affiliation":[{"name":"H. Milton Stewart School of Industrial and Systems Engineering Georgia Institute of Technology Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sridhar V.","family":"Basavaraju","sequence":"additional","affiliation":[{"name":"Office of Blood, Organ, and Other Tissue Safety, Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases Centers for Disease Control and Prevention Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian M.","family":"Gurbaxani","sequence":"additional","affiliation":[{"name":"H. Milton Stewart School of Industrial and Systems Engineering Georgia Institute of Technology Atlanta Georgia"},{"name":"Centers for Disease Control and Prevention Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Hammett","sequence":"additional","affiliation":[{"name":"National Center for Emerging and Zoonotic Infectious Diseases Centers for Disease Control and Prevention Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinar","family":"Keskinocak","sequence":"additional","affiliation":[{"name":"H. Milton Stewart School of Industrial and Systems Engineering Georgia Institute of Technology Atlanta Georgia"},{"name":"Center for Health and Humanitarian Systems Georgia Institute of Technology Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Sokol","sequence":"additional","affiliation":[{"name":"H. Milton Stewart School of Industrial and Systems Engineering Georgia Institute of Technology Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Kuehnert","sequence":"additional","affiliation":[{"name":"Office of Blood, Organ, and Other Tissue Safety, Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases Centers for Disease Control and Prevention Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2009.131332"},{"key":"e_1_2_9_3_1","unstructured":"Centers for Disease Control and Prevention.CDC Public Health Grand Rounds \u2010 Unusual Donor Derived Transplant\u2010associated Infections: Just How Unusual?;2014.https:\/\/www.cdc.gov\/cdcgrandrounds\/pdf\/gr-unusual-transplant-infections-11-18.pdf"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2008.00936.x"},{"issue":"36","key":"e_1_2_9_5_1","first-page":"1165","article-title":"Balamuthia mandrillaris transmitted through organ transplantation \u2013\u2010 Mississippi, 2009","volume":"59","author":"Centers for Disease Control and Prevention","year":"2010","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa053240"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2010.00595.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.03.042"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.7986"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit456"},{"key":"e_1_2_9_11_1","unstructured":"CohenE BonifieldJ.CDC: man died of rabies from kidney transplant;2013.www.cnn.com. March 16 2018."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12933"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03460.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03329.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12429"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12676"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12206"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.06.020"},{"key":"e_1_2_9_19_1","unstructured":"Organ Procurement and Transplantation Network.EPTS Calculator;2018.https:\/\/optn.transplant.hrsa.gov\/resources\/allocation-calculators\/epts-calculator\/. Accessed May 18 2018."},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e318145b9f7"},{"issue":"11","key":"e_1_2_9_21_1","first-page":"981","article-title":"iChoose kidney: a clinical decision aid for kidney transplantation vs. dialysis treatment","volume":"96","author":"Patzer R","year":"2015","journal-title":"Transplant"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02708.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02177.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24113"},{"issue":"45","key":"e_1_2_9_25_1","first-page":"1263","article-title":"West Nile Virus transmission via organ transplantation and blood transfusion \u2013\u2010 Louisiana, 2008","volume":"58","author":"Centers for Disease Control and Prevention","year":"2009","journal-title":"Morb Mortal Wkly Rep"},{"issue":"40","key":"e_1_2_9_26_1","first-page":"1021","article-title":"West Nile Virus infections in organ transplant recipients \u2013\u2010 New York and Pennsylvania, August\u2013September, 2005","volume":"54","author":"Centers for Disease Control and Prevention","year":"2005","journal-title":"Morb Mortal Wkly Rep"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022987"},{"issue":"36","key":"e_1_2_9_28_1","first-page":"1165","article-title":"Balamuthia mandrillaris transmitted through organ transplantation \u2013\u2010 Mississippi, 2009","volume":"59","author":"Centers for Disease Control and Prevention","year":"2010","journal-title":"Morb Mortal Wkly Rep"},{"issue":"9","key":"e_1_2_9_29_1","first-page":"9","article-title":"Balamuthia mandrillaris meningoencephalitis associated with solid organ transplantation \u2010 review of cases","volume":"7","author":"LaFleur M","year":"2013","journal-title":"J Radiol Case Rep"},{"issue":"36","key":"e_1_2_9_30_1","first-page":"1182","article-title":"Notes from the field: transplant\u2010transmitted balamuthia mandrillaris \u2013\u2010 Arizona, 2010","volume":"59","author":"Centers for Disease Control and Prevention","year":"2010","journal-title":"Morb Mortal Wkly Rep"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043018"},{"issue":"26","key":"e_1_2_9_32_1","first-page":"586","article-title":"Investigation of rabies infections in organ donor and transplant recipients \u2013\u2010 Alabama, Arkansas, Oklahoma, and Texas, 2004","volume":"53","author":"Centers for Disease Control and Prevention","year":"2004","journal-title":"Morb Mortal Wkly Rep"},{"key":"e_1_2_9_33_1","unstructured":"SillM.Lecture Notes Chapter 5: Cox Proportional Hazards Model;2004.http:\/\/www.gog.org\/sdcstaff\/mikesill\/classes\/sta575\/lectures\/LectureNotesChp5.pdf. Accessed April 5 2017."},{"key":"e_1_2_9_34_1","unstructured":"Swiss Federal Institute of Technology Zurich.Cox Proportional Hazards Model and its Characteristics;2011.http:\/\/stat.ethz.ch\/education\/semesters\/ss2011\/seminar\/contents\/presentation_3.pdf. Accessed April 5 2017."},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471722146"},{"key":"e_1_2_9_36_1","unstructured":"LangL.Expected decline in liver transplants due to lower quality donor liver;2013.http:\/\/news.unchealthcare.org\/news\/2013\/january\/liver. Accessed April 5 2017."},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080661"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00593.x"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200209000-00008"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051926"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.01.019"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw422"},{"key":"e_1_2_9_43_1","unstructured":"Organ Procurement and Transplantation Network.MELD serum sodium policy changes;2016.https:\/\/optn.transplant.hrsa.gov\/news\/meld-serum-sodium-policy-changes\/. Accessed November 2 2017."},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23398"},{"key":"e_1_2_9_45_1","unstructured":"RStudio Inc.Shiny from R Studio;2018.https:\/\/shiny.rstudio.com"},{"issue":"45","key":"e_1_2_9_46_1","first-page":"1263","article-title":"West Nile Virus transmission via organ transplantation and blood transfusion \u2014 Louisiana, 2008","volume":"58","author":"Centers for Disease Control and Prevention","year":"2009","journal-title":"Morb Mortal Wkly Rep"},{"issue":"40","key":"e_1_2_9_47_1","first-page":"1021","article-title":"West Nile Virus infections in organ transplant recipients \u2014 New York and Pennsylvania, August\u2013September, 2005","volume":"54","author":"Centers for Disease Control and Prevention","year":"2005","journal-title":"Morb Mortal Wkly Rep"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13115","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.13115","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T15:45:42Z","timestamp":1694274342000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.13115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,4]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/tid.13115"],"URL":"https:\/\/doi.org\/10.1111\/tid.13115","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"type":"print","value":"1398-2273"},{"type":"electronic","value":"1399-3062"}],"subject":[],"published":{"date-parts":[[2019,6,4]]},"assertion":[{"value":"2018-10-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13115"}}