{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:29:22Z","timestamp":1791980962202,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T00:00:00Z","timestamp":1559520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Treatment of symptomatic candiduria is notoriously challenging because of the limited repository of antifungals that achieve adequate urinary concentrations. Fluconazole, amphotericin B\u2010based products, and flucytosine are established treatment options for most <jats:italic>Candida<\/jats:italic> species. <jats:italic>Candida krusei<\/jats:italic> exhibits intrinsic resistance to fluconazole and decreased susceptibility to amphotericin B and flucytosine. In transplant patients, both amphotericin B\u2010based products and flucytosine are less desirable because of their toxicities. Other triazole antifungals are unappealing because they do not achieve adequate urinary concentrations, have multiple toxicities, and interact with transplant\u2010related immunosuppressive medications. Echinocandins are well\u2010tolerated but have been traditionally deferred in the treatment of symptomatic funguria because of their poor urinary concentrations but there is a small but emerging body of literature supporting their use. Here, we present a case of successful eradication of chronic symptomatic <jats:italic>C<\/jats:italic>\u00a0<jats:italic>krusei<\/jats:italic> urinary tract infection with micafungin 150 milligrams daily in a liver and kidney transplant recipient, and we review the literature on treatment of symptomatic candiduria.<\/jats:p>","DOI":"10.1111\/tid.13118","type":"journal-article","created":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T05:33:08Z","timestamp":1558416788000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Successful eradication of chronic symptomatic <i>Candida krusei<\/i> urinary tract infection with increased dose micafungin in a liver and kidney transplant recipient: Case report and review of the literature"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4043-4287","authenticated-orcid":false,"given":"Ashrit","family":"Multani","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases &amp; Geographic Medicine, Department of Medicine Stanford University School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aruna K.","family":"Subramanian","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases &amp; Geographic Medicine, Department of Medicine Stanford University School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Y.","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases &amp; Geographic Medicine, Department of Medicine Stanford University School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir109"},{"issue":"11","key":"e_1_2_7_3_1","first-page":"B4698","article-title":"Candida and candidaemia. 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