{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:51:47Z","timestamp":1756993907193,"version":"3.41.2"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T00:00:00Z","timestamp":1560816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cytomegalovirus (CMV) disease represents a serious complication in liver transplant (OLT) recipients. CMV prophylaxis reduces incidence of CMV disease in the early post\u2010transplant period (on\u2010prophylaxis disease, OPD) but may postpone its manifestation after the completion of prophylaxis. Post\u2010prophylaxis disease (PPD) incidence after prophylaxis cessation may be modified by genetic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed impact of <jats:italic>IL28B<\/jats:italic> rs1297986 variants on CMV disease incidence in 743 adult OLT recipients receiving universal prophylaxis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and forty\u2010four (19.4%) patients had at least one CMV disease episode. One hundred and two of them (70.8%) had at least one OPD and 36 (25%) patients had PPD, six (4.2%) patients had both. The rate of <jats:italic>IL28B<\/jats:italic> T allele carriers was lower in PPD group (38.9%) in comparison with OPD group (66.7%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.005) and group without CMV disease (61.4%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.009). The impact of <jats:italic>IL28B<\/jats:italic> genotype on the risk of CMV OPD was significant neither in the allelic (TT\u00a0+\u00a0CT vs CC, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.32) nor in the recessive model (TT vs CT\u00a0+\u00a0CC, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.79). Contrarily, in the PPD group, T allele (TT\u00a0+\u00a0CT vs CC) had a protective effect, OR 0.4 (95% CI 0.2\u20100.8, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.008). Further risk factors of PPD were age &lt;55\u00a0years and valganciclovir prophylaxis, whereas the risk factors of OPD were age &lt;55\u00a0years, cyclosporine A therapy and pre\u2010transplant CMV serostatus (donor +\/recipient \u2212).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>IL28B<\/jats:italic> rs12979860 T allele carriers had a lower risk of CMV PPD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13124","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T08:50:55Z","timestamp":1559724655000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<i>IL28B<\/i> rs12979860 T allele protects against CMV disease in liver transplant recipients in the post\u2010prophylaxis and late period"],"prefix":"10.1111","volume":"21","author":[{"given":"Klara","family":"Chmelova","sequence":"first","affiliation":[{"name":"Department of Hepatogastroenterology Institute for Clinical and Experimental Medicine Prague Czech Republic"},{"name":"First Faculty of Medicine Charles University Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1462-5920","authenticated-orcid":false,"given":"Sona","family":"Frankova","sequence":"additional","affiliation":[{"name":"Department of Hepatogastroenterology Institute for Clinical and Experimental Medicine Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Jirsa","sequence":"additional","affiliation":[{"name":"First Faculty of Medicine Charles University Prague Czech Republic"},{"name":"Laboratory of Experimental Hepatology Institute for Clinical and Experimental Medicine Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Neroldova","sequence":"additional","affiliation":[{"name":"First Faculty of Medicine Charles University Prague Czech Republic"},{"name":"Laboratory of Experimental Hepatology Institute for Clinical and Experimental Medicine Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Sticova","sequence":"additional","affiliation":[{"name":"Department of Clinical and Transplant Pathology Institute for Clinical and Experimental Medicine Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dusan","family":"Merta","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Resuscitation and Intensive Care Institute for Clinical and Experimental Medicine Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Senkerikova","sequence":"additional","affiliation":[{"name":"Department of Hepatogastroenterology Institute for Clinical and Experimental Medicine Prague Czech Republic"},{"name":"First Faculty of Medicine Charles University Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Trunecka","sequence":"additional","affiliation":[{"name":"Department of Hepatogastroenterology Institute for Clinical and Experimental Medicine Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julius","family":"Spicak","sequence":"additional","affiliation":[{"name":"Department of Hepatogastroenterology Institute for Clinical and Experimental Medicine Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Sperl","sequence":"additional","affiliation":[{"name":"Department of Hepatogastroenterology Institute for Clinical and Experimental Medicine Prague Czech Republic"},{"name":"First Faculty of Medicine Charles University Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.655"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02897.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/62.suppl_1.S7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00382.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)05535-9"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03074.x"},{"key":"e_1_2_7_8_1","first-page":"CD005133","article-title":"Pre\u2010emptive treatment for cytomegalovirus viraemia to prevent cytomegalovirus disease in solid organ transplant recipients","volume":"1","author":"Strippoli GF","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000228232.09678.6b"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23460"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v2.i9.325"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/318724"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199905133401903"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e328236742e"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis818"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.01.039"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir819"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13107"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24676"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000379"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu144"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23865"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/gm273"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130012"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni875"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08309"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2521"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12110"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000342526"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25749"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu557"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01207.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12447"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2004.00033.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.4.1498-1504.2004"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.07.019"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.449"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.447"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.06.035"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i18.5496"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04186-7"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2015.11"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6699"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(02)00334-X"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-71767-8_22"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2009.0064"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/v6041502"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01164-09"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002016"},{"issue":"3","key":"e_1_2_7_50_1","first-page":"155","article-title":"Prognosis value of the pp65 antigenemia and semi\u2010quantitative PCR in the detection of the CMV reactivation in bone marrow grafted patients","volume":"99","author":"Ksouri H","year":"2006","journal-title":"Bull Soc Pathol Exot"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02369.x"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.7182\/pit2015558"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.07020714"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit945"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13124","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.13124","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T15:45:22Z","timestamp":1694274322000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.13124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,18]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/tid.13124"],"URL":"https:\/\/doi.org\/10.1111\/tid.13124","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"type":"print","value":"1398-2273"},{"type":"electronic","value":"1399-3062"}],"subject":[],"published":{"date-parts":[[2019,6,18]]},"assertion":[{"value":"2019-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13124"}}