{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T13:33:58Z","timestamp":1789047238955,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T00:00:00Z","timestamp":1561420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cytomegalovirus (CMV) outcomes with valganciclovir prophylaxis in renal transplant recipients experiencing delayed graft function (DGF) are unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single center, retrospective, cohort study of CMV high\u2010risk (D+\/R\u2212 with alemtuzumab induction) deceased donor renal transplant recipients receiving valganciclovir prophylaxis assessed CMV outcomes in patients experiencing DGF (n\u00a0=\u00a072) versus those with immediate graft function (IGF; n\u00a0=\u00a066).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cytomegalovirus viremia by 12\u00a0months occurred at similar rates in the IGF and DGF groups (30.3% vs 26.4%, respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.71) with 89.7% (35\/39) of all cases classified as CMV disease. The median time to CMV viremia post transplant was day 141 and 138 in the IGF and DGF groups, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.30). The incidence of biopsy\u2010proven acute rejection (BPAR) was higher in the DGF group (18.1% vs 4.6%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) with BPAR preceding CMV in only 1 patient. There was no significant difference in graft loss (1.5% vs 4.2%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.62) or patient survival (98.5% vs 95.8%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.62) at 1 year between the IGF and DGF groups, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Valganciclovir prophylaxis in patients experiencing DGF yielded similar CMV outcomes up to 1\u2010year post transplant when compared to use in patients with IGF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13125","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T08:49:30Z","timestamp":1559724570000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical outcomes of valganciclovir prophylaxis in high\u2010risk (D+\/R\u2212) renal transplant recipients experiencing delayed graft function"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0055-0040","authenticated-orcid":false,"given":"Sari R.","family":"Freedman","sequence":"first","affiliation":[{"name":"Department of Pharmacy University of Maryland Medical Center Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2232-8894","authenticated-orcid":false,"given":"Bharath R.","family":"Ravichandran","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Maryland Medical Center Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1841-5135","authenticated-orcid":false,"given":"Brian M.","family":"Masters","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Maryland Medical Center Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1407-8795","authenticated-orcid":false,"given":"Jonathan S.","family":"Bromberg","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Maryland School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1810-7987","authenticated-orcid":false,"given":"Abdolreza","family":"Haririan","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Maryland School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kapil K.","family":"Saharia","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine University of Maryland School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6644-6684","authenticated-orcid":false,"given":"Emily L.","family":"Heil","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Maryland Medical Center Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8305-7296","authenticated-orcid":false,"given":"Tracy","family":"Sparkes","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Maryland Medical Center Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/62.suppl_1.S7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14208"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3947\/ic.2013.45.3.260"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002191"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/597089"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01910.x"},{"key":"e_1_2_8_8_1","unstructured":"Product monograph valcyte\u00aeHoffmann\u2010La Roche Ltd. 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