{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:07:04Z","timestamp":1790064424204,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T00:00:00Z","timestamp":1564531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Post\u2010transplant lymphoproliferative disorders (PTLD) are associated with significant morbidity and mortality following allogeneic hematopoietic cell transplant (alloHCT). Although most PTLD is EBV\u2010positive (EBV<jats:sup>pos<\/jats:sup>), EBV\u2010negative (EBV<jats:sup>neg<\/jats:sup>) PTLD is reported, yet its incidence and clinical impact remain largely undefined. Furthermore, factors at the time of transplant impacting survival following PTLD are not well described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 2002 and 2014, 432 cases of PTLD following alloHCT were reported to the Center for International Blood and Marrow Transplant Research (CIBMTR). After exclusions, 267 cases (EBV<jats:sup>pos\u00a0<\/jats:sup>=\u00a0222, 83%; EBV<jats:sup>neg\u00a0<\/jats:sup>=\u00a045, 17%) were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and eight patients (78%) received in vivo T\u2010cell depletion (TCD) with either anti\u2010thymocyte globulin (ATG) or alemtuzumab. Incidence of PTLD was highest using umbilical cord donors (UCB, 1.60%) and lowest using matched related donors (MRD, 0.40%). Clinical features and histology did not significantly differ among EBV<jats:sup>pos<\/jats:sup> or EBV<jats:sup>neg <\/jats:sup>PTLD cases except that absolute lymphocyte count recovery was slower, and CMV reactivation was later in EBV<jats:sup>neg<\/jats:sup> PTLD [EBV<jats:sup>pos<\/jats:sup> 32 (5\u201095) days versus EBV<jats:sup>neg<\/jats:sup> 47 (10\u201070) days, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.016]. There was no impact on survival by EBV status in multivariable analysis [EBV<jats:sup>neg<\/jats:sup> RR 1.42, 95% CI 0.94\u20102.15, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.097].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is no difference in survival outcomes for patients with EBV<jats:sup>pos<\/jats:sup> or EBV<jats:sup>neg<\/jats:sup> PTLD occurring following alloHCT and 1\u2010year survival is poor. Features of conditioning and use of serotherapy remain important.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13145","type":"journal-article","created":{"date-parts":[[2019,7,13]],"date-time":"2019-07-13T06:19:14Z","timestamp":1562998754000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Survival outcomes of allogeneic hematopoietic cell transplants with EBV\u2010positive or EBV\u2010negative post\u2010transplant lymphoproliferative disorder, A CIBMTR study"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9859-151X","authenticated-orcid":false,"given":"Seema","family":"Naik","sequence":"first","affiliation":[{"name":"Penn State Cancer Institute Hershey Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcie","family":"Riches","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology The University of North Carolina Chapel Hill North California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parameswaran","family":"Hari","sequence":"additional","affiliation":[{"name":"Department of Medicine, Medical College of Wisconsin Center for International Blood and Marrow Transplant Research (CIBMTR) Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medicine, Medical College of Wisconsin Center for International Blood and Marrow Transplant Research (CIBMTR) Milwaukee Wisconsin"},{"name":"Division of Biostatistics, Institute for Health and Equity Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Medical College of Wisconsin Center for International Blood and Marrow Transplant Research (CIBMTR) Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Bachier","sequence":"additional","affiliation":[{"name":"Sarah Cannon Center for Blood Cancer Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Shaughnessy","sequence":"additional","affiliation":[{"name":"Texas Transplant Institute Sarah Cannon Blood Cancer Network San Antonio Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Hill","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Ljungman","sequence":"additional","affiliation":[{"name":"Department of Cellular Therapy and Allogeneic Stem Cell Transplantation Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoo","family":"Battiwalla","sequence":"additional","affiliation":[{"name":"Sarah Cannon Center for Blood Cancer Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh","family":"Chhabra","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for International Blood and Marrow Transplant Research (CIBMTR) Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Daly","sequence":"additional","affiliation":[{"name":"Tom Baker Cancer Centre Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Storek","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Calgary Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celalettin","family":"Ustun","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology and Transplantation, Department of Medicine University of Minnesota Medical Center Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Angel","family":"Diaz","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Hospital Infantil Universitario Nino Jesus Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Cerny","sequence":"additional","affiliation":[{"name":"UMass Memorial Medical Center Worcester Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amer","family":"Beitinjaneh","sequence":"additional","affiliation":[{"name":"University of Miami Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Yared","sequence":"additional","affiliation":[{"name":"Blood &amp; Marrow Transplantation Program, Division of Hematology\/Oncology, Department of Medicine, Greenebaum Cancer Center University of Maryland Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology\/Hematology, Department of Pediatrics Penn State Hershey Children's Hospital and College of Medicine Hershey Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Page","sequence":"additional","affiliation":[{"name":"Division of Pediatric Blood and Marrow Transplantation Duke University Medical Center Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parastoo B.","family":"Dahi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Adult Bone Marrow Transplant Service Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddhartha","family":"Ganguly","sequence":"additional","affiliation":[{"name":"Division of Hematological Malignancy and Cellular Therapeutics University of Kansas Health System Kansas City Kansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology Dokkyo Medical University Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson","family":"Chao","sequence":"additional","affiliation":[{"name":"Division of Cell Therapy and Hematologica, Department of Medicine Duke University Medical Center Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar O.","family":"Freytes","sequence":"additional","affiliation":[{"name":"Texas Transplant Institute Sarah Cannon Blood Cancer Network San Antonio Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"Saad","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bipin N.","family":"Savani","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine Vanderbilt University Medical Center Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang","family":"Woo Ahn","sequence":"additional","affiliation":[{"name":"Department of Medicine, Medical College of Wisconsin Center for International Blood and Marrow Transplant Research (CIBMTR) Milwaukee Wisconsin"},{"name":"Division of Biostatistics, Institute for Health and Equity Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Boeckh","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division Fred Hutchinson Cancer Research Center Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen E.","family":"Heslop","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Center for Cell and Gene Therapy Baylor College of Medicine Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hillard M.","family":"Lazarus","sequence":"additional","affiliation":[{"name":"Seidman Cancer Center, University Hospitals Cleveland Medical Center Case Western Reserve University Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery J.","family":"Auletta","sequence":"additional","affiliation":[{"name":"Blood and Marrow Transplant Program and Host Defense Program, Divisions of Hematology\/Oncology\/Bone Marrow Transplant and Infectious Diseases Nationwide Children's Hospital Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rammurti T.","family":"Kamble","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Center for Cell and Gene Therapy Baylor College of Medicine Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2008-0036"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.56.082103.104727"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-143545"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.11-6-674"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.6.2052"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.4.972"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1600-6143.2003.00325.x"},{"issue":"7","key":"e_1_2_6_9_1","first-page":"2208","article-title":"Risk of lymphoproliferative disorders after bone marrow transplantation: a multi\u2010institutional study","volume":"94","author":"Curtis RE","year":"1999","journal-title":"Blood"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-09-178046"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-011791"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2008.394"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.8.3079.3079_3079_3083"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-010-9635-8"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.07.004"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.12.497"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.04.003"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.144428"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.2.812.bloodjournal872812"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13558"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.07.035"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200003150-00027"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13324"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200003000-00006"},{"key":"e_1_2_6_25_1","first-page":"2823","article-title":"EBV\u2010Negative Post\u2010Transplant Lymphoproliferative Disorder (PTLD): A Retrospective Case\u2010Control Study of Clinical and Pathological Characteristics","volume":"112","author":"Reshef R","year":"2008","journal-title":"Response to Treatment and Survival. Blood"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2013.170"},{"issue":"2","key":"e_1_2_6_27_1","first-page":"377","article-title":"Risk factors for developing EBV\u2010related B cell lymphoproliferative disorders (BLPD) after non\u2010HLA\u2010identical BMT in children","volume":"18","author":"Gerritsen EJ","year":"1996","journal-title":"Bone Marrow Transplant"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13145","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.13145","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T09:57:32Z","timestamp":1694253452000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.13145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,31]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1111\/tid.13145"],"URL":"https:\/\/doi.org\/10.1111\/tid.13145","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,31]]},"assertion":[{"value":"2019-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13145"}}