{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:41:56Z","timestamp":1773034916487,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T00:00:00Z","timestamp":1567468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is growing evidence that community\u2010acquired respiratory virus (CARV) increases the risk of pulmonary invasive fungal disease (IFD) in the allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT) setting. To date, there is a lack of knowledge regarding the risk factors (RFs), as well as the most critical period for subsequent onset of IFD after CARV infections in allo\u2010HSCT recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective longitudinal observational CARV survey, we analyzed the effect of CARV on subsequent IFD development in 287 adult allo\u2010HSCT recipients diagnosed with 597 CARV episodes from December 2013 to December 2018. Multiplex PCR panel assays were used to test CARVs in respiratory specimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>Twenty\u2010nine out of 287 allo\u2010HSCT recipients (10%) developed IFD after a CARV episode. The median time of IFD onset was 21\u00a0days (range, 0\u2010158\u00a0days) from day of the first CARV detection. Generalized estimating equation model identified 4 risk factors for IFD: ATG\u2010based conditioning regimen [odds ratio (OR) 2.34, 95% confidence interval (CI) 1.05\u20105.2, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.038], CARV lower respiratory tract disease (OR 10.6, 95% CI 3.7\u201030.8, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001), CARV infection during the first year after transplant (OR 5.34, 95% CI 1.3\u201021.8, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.014), and corticosteroids during CARV (OR 2.6, 95% CI 1.1\u20106.3, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Allo\u2010HSCT recipients conditioned with ATG and under corticosteroid therapy at the time of CARV LRTD during the first year after transplant may require close monitoring for subsequent IFD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13158","type":"journal-article","created":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T06:42:49Z","timestamp":1565592169000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Incidence, risk factors, and outcome of pulmonary invasive fungal disease after respiratory virus infection in allogeneic hematopoietic stem cell transplantation recipients"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8533-2562","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Pi\u00f1ana","sequence":"first","affiliation":[{"name":"Hematology Department Hospital Universitari i Polit\u00e8cnic La Fe Valencia Spain"},{"name":"CIBERONC, Instituto Carlos III Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Dolores","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Microbiology 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INCLIVA Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva Mar\u00eda","family":"Gonz\u00e1lez\u2010Barber\u00e1","sequence":"additional","affiliation":[{"name":"Microbiology Department Hospital Universitari i Polit\u00e8cnic La Fe Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Carretero","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitari i Polit\u00e8cnic La Fe Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Guerreiro","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitari i Polit\u00e8cnic La Fe Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Salavert","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hospital Universitari i Polit\u00e8cnic La Fe Valencia 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