{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:27:09Z","timestamp":1759400829610,"version":"3.41.2"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,9,15]],"date-time":"2019-09-15T00:00:00Z","timestamp":1568505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Direct\u2010acting antivirals (DAAs) demonstrated high efficacy and safety even in the post\u2010liver transplant (LT) setting and in HIV\u2010infected patients, but data are very limited in the early post\u2010LT period with the most recently available DAA. Two HIV\/HCV\u2010coinfected LT recipients (both grafts from HIV\/HCV\u2010negative donors) experienced early HCV recurrence with severe hepatitis and were treated with sofosbuvir\/velpatasvir for 12\u00a0weeks. Unfortunately, both patients failed: one (genotype 4d) showed virological breakthrough at week 3 with resistance\u2010associated substitutions (RASs) for both NS5A and NS5B, while the other (genotype 1a) experienced virological relapse without RAS. Both progressed to fibrosing cholestatic hepatitis and were successfully retreated with glecaprevir\/pibrentasvir for 16\u00a0weeks achieving sustained virological response. The higher prevalence of RAS in experienced genotype 4 patients and the long time to viral suppression observed in subjects with fibrosing cholestatic hepatitis should be taken into account, considering longer treatment duration to increase the chances of achieving sustained virological response.<\/jats:p>","DOI":"10.1111\/tid.13165","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T15:19:30Z","timestamp":1567696770000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sustained virological response with 16\u2010week glecaprevir\/pibrentasvir after failure to sofosbuvir\/velpatasvir in post\u2010transplant severe HCV recurrence in HIV"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5081-8669","authenticated-orcid":false,"given":"Marco","family":"Merli","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases ASST Grande Ospedale Metropolitano Niguarda Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Rossotti","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases ASST Grande Ospedale Metropolitano Niguarda Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Travi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases ASST Grande Ospedale Metropolitano Niguarda Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Ferla","sequence":"additional","affiliation":[{"name":"Division of General Surgery &amp; Abdominal Transplantation ASST Grande Ospedale Metropolitano Niguarda Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Lauterio","sequence":"additional","affiliation":[{"name":"Division of General Surgery &amp; Abdominal Transplantation ASST Grande Ospedale Metropolitano Niguarda Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Angelini Zucchetti","sequence":"additional","affiliation":[{"name":"Division of Pharmacy ASST Grande Ospedale Metropolitano Niguarda Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Alcantarini","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Unit of Infectious Diseases Amedeo di Savoia Hospital University of Torino Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Bargiacchi","sequence":"additional","affiliation":[{"name":"Infectious Diseases Section \u201cMaggiore della Carit\u00e0\u201d Hospital Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano","family":"De Carlis","sequence":"additional","affiliation":[{"name":"Division of General Surgery &amp; Abdominal Transplantation ASST Grande Ospedale Metropolitano Niguarda Milano Italy"},{"name":"School of Medicine University of Milano\u2010Bicocca Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Puoti","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases ASST Grande Ospedale Metropolitano Niguarda Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23411"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04028.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001928"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14996"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001704"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.05.039"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30046"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29671"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofx065"},{"issue":"1","key":"e_1_2_7_11_1","first-page":"128A","article-title":"A real world resistance profile of virologic failures collected from an international collaboration (SHARED)","volume":"68","author":"Howe A","year":"2018","journal-title":"Hepatology"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2018.09.010"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.06.021"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1611829"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13165","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.13165","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T22:25:19Z","timestamp":1694211919000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.13165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,15]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/tid.13165"],"URL":"https:\/\/doi.org\/10.1111\/tid.13165","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"type":"print","value":"1398-2273"},{"type":"electronic","value":"1399-3062"}],"subject":[],"published":{"date-parts":[[2019,9,15]]},"assertion":[{"value":"2019-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13165"}}