{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:18:40Z","timestamp":1780589920297,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T00:00:00Z","timestamp":1571097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2016M3A9D3026905"],"award-info":[{"award-number":["2016M3A9D3026905"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002552","name":"Seoul National University of Education","doi-asserted-by":"publisher","award":["800\u201020190259"],"award-info":[{"award-number":["800\u201020190259"]}],"id":[{"id":"10.13039\/501100002552","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The efficacy of preemptive treatment containing rituximab to prevent post\u2010transplant lymphoproliferative disease (PTLD) in children has not yet been fully elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 19 pediatric patients who developed high Epstein\u2010Barr virus (EBV) DNAemia (EBV viral load of greater than 40\u00a0000\u00a0copies\/mL) after allogeneic hematopoietic stem cell transplantation (HSCT) and were preemptively administered rituximab. Rituximab was intravenously injected at a dose of 375\u00a0mg\/m<jats:sup>2<\/jats:sup> once the EBV viral load was greater than 40\u00a0000\u00a0copies\/mL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all 19 patients, EBV DNAemia was eradicated after a median of 9\u00a0days (range, 3\u201020\u00a0days), and PTLD did not occur. One patient had transient fever, and four patients did not fully recover B cell counts after transplantation. We suggested that delayed B cell recovery was caused by chronic graft\u2010versus\u2010host disease (GVHD) related drugs, not rituximab administration. And there were no other infection\u2010related side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion, preemptive therapy containing rituximab is expected to reduce the incidence of PTLD after HSCT and improve post\u2010transplantation outcomes in children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13182","type":"journal-article","created":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T07:44:11Z","timestamp":1569483851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Successful preemptive therapy with single\u2010dose rituximab for Epstein\u2010Barr virus infection to prevent post\u2010transplant lymphoproliferative disease after pediatric hematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"21","author":[{"given":"Bo Kyung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Pediatrics Seoul National University College of Medicine Seoul Korea"},{"name":"Seoul National University Cancer Research Institute Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1009-6002","authenticated-orcid":false,"given":"Hyoung Jin","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seoul National University College of Medicine Seoul Korea"},{"name":"Seoul National University Cancer Research Institute Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Taek","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seoul National University College of Medicine Seoul Korea"},{"name":"Seoul National University Cancer Research Institute Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Yul","family":"An","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seoul National University College of Medicine Seoul 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