{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T23:20:15Z","timestamp":1785280815325,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T00:00:00Z","timestamp":1570752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Clostridioides difficile<\/jats:italic> infection (CDI) is common after solid organ transplant (SOT) and is associated with high morbidity and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed incidence, risk factors, and outcomes of CDI among SOT patients at a large multi\u2010organ transplant center. Multivariable logistic regression was used to identify risk factors for initial and recurrent CDI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 2622 SOT patients were included. 224 (8.5%) had CDI 1\u00a0year post\u2010SOT. The highest incidence of CDI was among pancreas recipients (12.5%) followed by lung (11.7%), liver (11.0%), heart (10.8%), and kidney (5.8%). Median time to CDI was 56\u00a0days (range 2\u2010354) post\u2010SOT. About 64% of patients had severe CDI. About 56.3% were treated with metronidazole, 13.8% with oral vancomycin, and 28.6% with both. About 28.6% of patients had recurrent CDI. In multivariable modeling, lung transplant recipient status was the only significant predictor of recurrent CDI (OR 4.97, 95% CI 2.11\u201011.78, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) controlling for age, severe CDI, and pre\u2010SOT CDI. Post\u2010SOT CDI nearly doubled the risk of mortality at one year, in particular among those with severe CDI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In summary, CDI is highly prevalent, occurs early in the post\u2010transplant period, usually severe, with a high rate of recurrence, and associated with increased mortality within 1\u00a0year after transplant. The early post\u2010transplant period may be a crucial window to reduce CDI rates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13184","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T05:44:16Z","timestamp":1569908656000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["<i>Clostridioides difficile<\/i> infection and recurrence among 2622 solid organ transplant recipients"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0758-7882","authenticated-orcid":false,"given":"Aaron","family":"Schluger","sequence":"first","affiliation":[{"name":"Department of Medicine Westchester Medical Center Valhalla NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3981-7053","authenticated-orcid":false,"given":"Russell","family":"Rosenblatt","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases Columbia University Irving Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Knotts","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases Columbia University Irving Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9658-3751","authenticated-orcid":false,"given":"Elizabeth C.","family":"Verna","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases Columbia University Irving Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9214-9122","authenticated-orcid":false,"given":"Marcus R.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Columbia University Irving Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1306801"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2013.05.028"},{"key":"e_1_2_8_4_1","unstructured":"SteinerC TerrelL.Healthcare Cost and Utilization Projections:Clostridium DifficileInfection 2011 to 20122012. 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