{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:42:23Z","timestamp":1753879343795,"version":"3.41.2"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T00:00:00Z","timestamp":1571011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["Solid Organ Transplantation in HIV: Multi\u2010Site Stu"],"award-info":[{"award-number":["Solid Organ Transplantation in HIV: Multi\u2010Site Stu"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypogammaglobulinemia (HGG) frequently occurs in recipients after types of (SOT). The incidence and significance of HGG in HIV+\u00a0recipients of SOT are just being explored. We reported that 12% of the recipients in the SOT in multi\u2010center HIV\u2010TR (HIV\u2010TR) Study developed moderate or severe HGG at 1\u00a0year. In LT recipients, this was associated with serious infections and death. We have now further characterized the decreased antibodies in HIV+\u00a0SOT recipients who developed HGG. We measured the levels of pathogen\u2010specific antibodies and poly\u2010specific self\u2010reactive antibodies (PSA) in relation to total IgG levels from serial serum samples for 20 HIV+\u00a0SOT recipients who developed moderate to severe HGG following SOT. Serum antibody levels to measles, tetanus toxoid, and HIV\u20101 were determined by EIA. Levels of PSAs were determined by incubating control lymphocytes with patient serum, staining with anti\u2010human IgG Fab\u2010FITC, and analysis by flow cytometry. Levels of PSA were higher compared to healthy, HIV\u2010uninfected controls at pre\u2010transplant baseline and increased by weeks 12 and 26, but the changes were not significant. Likewise, anti\u2010HIV antibody levels remained unchanged over time. In contrast, antibody levels against measles and tetanus were significantly reduced from baseline by week 12, and did not return to baseline, even after 2\u00a0years. For HIV patients who develop moderate to severe HGG after transplant, the reduction in IgG levels is associated with a significant decrease in pathogen\u2010specific antibody titers, while PSA levels and anti\u2010HIV antibodies are unchanged. This may contribute to infectious complications and other clinical endpoints.<\/jats:p>","DOI":"10.1111\/tid.13188","type":"journal-article","created":{"date-parts":[[2019,10,6]],"date-time":"2019-10-06T08:46:30Z","timestamp":1570351590000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Acquired hypogammaglobulinemia and pathogen\u2010specific antibody depletion after solid organ transplantation in human immunodeficiency virus infection: A brief report"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2181-1780","authenticated-orcid":false,"given":"Margaret","family":"Newman","sequence":"first","affiliation":[{"name":"Section of Infectious Diseases and Global Health University of Chicago Medicine Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Gregg","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases University of Michigan Ann Arbor MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randee","family":"Estes","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases and Global Health University of Chicago Medicine Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Pursell","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases and Global Health University of Chicago Medicine Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6663-2436","authenticated-orcid":false,"given":"David","family":"Pitrak","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases and Global Health University of Chicago Medicine Chicago 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