{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T19:22:29Z","timestamp":1780428149386,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T00:00:00Z","timestamp":1573776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Trimethoprim\u2010sulfamethoxazole (TMP\u2010SMX) is the first\u2010line agent for <jats:italic>Pneumocystis jiroveci<\/jats:italic> pneumonia (PJP) prophylaxis for solid organ transplant (SOT) recipients because of its efficacy for this indication, extended antimicrobial coverage, and favorable cost. Reported sulfonamide allergy is not uncommon and often results in TMP\u2010SMX avoidance. Desensitization offers an efficacious and cost\u2010effective alternative to TMP\u2010SMX avoidance. Herein, we reviewed our experience with desensitization during the index transplant hospitalization among 52 SOT recipients with history of a non\u2010anaphylactic sulfonamide allergy. Of those enrolled in the desensitization protocol, 92% (48\/52) completed the protocol, with nearly 80% (41\/52) still on TMP\u2010SMX at 3\u00a0months without adverse reaction. Eleven patients discontinued TMP\u2010SMX (7 for allergic reactions and 4 for non\u2010allergic reasons) and switched to pentamidine. A cost savings of $575 per desensitization was calculated based on annual wholesale drug prices, for a total savings of $23\u00a0575. Additionally, the protocol did not delay discharge in any patient nor was it associated with any severe allergic reactions. These findings suggest TMP\u2010SMX desensitization is safe and effective in SOT recipients with a history of non\u2010anaphylactic, non\u2010life\u2010threatening sulfonamide hypersensitivity.<\/jats:p>","DOI":"10.1111\/tid.13191","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T14:59:36Z","timestamp":1570633176000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Sulfonamide desensitization in solid organ transplant recipients: A protocol\u2010driven approach during the index transplant hospitalization"],"prefix":"10.1111","volume":"21","author":[{"given":"Joseph B.","family":"Pryor","sequence":"first","affiliation":[{"name":"School of Medicine Oregon Health &amp; Science University Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali J.","family":"Olyaei","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Oregon Health &amp; Science University\/Oregon State University Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Kirsch","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Beaumont Hospital Dearborn MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2309-8146","authenticated-orcid":false,"given":"Lynne","family":"Strasfeld","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Oregon Health &amp; Science University Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14208"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12119"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022963"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12124"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13546"},{"issue":"256","key":"e_1_2_6_7_1","first-page":"3358","article-title":"Drug\u2010induced cutaneous reactions. A report from the Boston Collaborative Drug Surveillance Program on 15,438 consecutive inpatients, 1975 to 1982","volume":"1986","author":"Bigby M","year":"1975","journal-title":"JAMA"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-018-0791-9"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit949"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/323353"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10196"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.111.4.1147-a"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-105-1-148"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14498"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12769"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18061316"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12968"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01079.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000006"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.05.051"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.13191","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13191","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.13191","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T22:25:38Z","timestamp":1694211938000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.13191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,15]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/tid.13191"],"URL":"https:\/\/doi.org\/10.1111\/tid.13191","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,15]]},"assertion":[{"value":"2019-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13191"}}