{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:46:24Z","timestamp":1753879584102,"version":"3.41.2"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T00:00:00Z","timestamp":1582675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Crusted scabies (CS) is a rare, severe and highly contagious form of scabies, which has been reported in immunosuppressed patients. A high index of suspicion and awareness of CS is essential to treat this infestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>A 13\u2010year\u2010old boy presented with pruritic hyperkeratotic squamous plaques located on both inner wrists, the web spaces of both his hands and his feet, and the genital area of 12\u00a0months duration. He was diagnosed with focal segmental glomerulosclerosis at the age of 5 and received a kidney transplant at the age of 9. He has been on a maintenance dose of prednisone (5\u00a0mg\/d) and mycophenolate mofetil (250\u00a0mg\/d) for the past 2\u00a0years. He had a contact history with a school friend with similar lesions. A skin punch biopsy demonstrated the presence of multiple mites in the stratum corneum confirming the diagnosis of CS. Ivermectin, the recommended drug of choice for crusted scabies, is not available in South Africa. The patient was commenced on topical benzoyl benzoate lotion but discontinued its use because of intolerable irritation. We subsequently prescribed the daily application of topical 5% sulfur in petrolatum to which his pruritus subsided significantly after 2\u00a0weeks with resolution of all skin lesions at the end of 8\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case is the first documented report of CS in a pediatric renal transplant patient. Our management highlights that classic formularies of magistral drugs are still effective treatment options and can be used especially when standard therapies cannot be tolerated or when optimum treatments are not available.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13193","type":"journal-article","created":{"date-parts":[[2019,10,12]],"date-time":"2019-10-12T20:53:20Z","timestamp":1570913600000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Crusted scabies in a pediatric renal transplant recipient on immunosuppressants"],"prefix":"10.1111","volume":"22","author":[{"given":"Chioma","family":"Ede","sequence":"first","affiliation":[{"name":"Division of Dermatology Faculty of Health Sciences University of the Witwatersrand Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8541-9246","authenticated-orcid":false,"given":"Ozge","family":"Gunduz","sequence":"additional","affiliation":[{"name":"Division of Dermatology Faculty of Health Sciences University of the Witwatersrand Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepak","family":"Modi","sequence":"additional","affiliation":[{"name":"Division of Dermatology Faculty of Health Sciences University of the Witwatersrand Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,26]]},"reference":[{"volume-title":"Treatment of Leprosy or Greek Elephantiasis","year":"1848","author":"Danielsen DG","key":"e_1_2_5_2_1"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2004.08.033"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002387"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2019.01.057"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00195-10"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13077"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-4065.65302"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1987.01660250101029"},{"key":"e_1_2_5_10_1","first-page":"66","article-title":"Crusted scabies in an 8\u2010year\u2010old child","volume":"13","author":"Dragos V","year":"2004","journal-title":"Acta Dermatoven APA"},{"key":"e_1_2_5_11_1","article-title":"Part I\u2013ectoparasites: scabies","author":"Thomas C","year":"2019","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.01.004"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14351"},{"key":"e_1_2_5_14_1","first-page":"427","article-title":"The use of sulphur in dermatology","volume":"3","author":"Gupta AK","year":"2004","journal-title":"J Drugs Dermatol"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13193","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.13193","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T09:14:09Z","timestamp":1693818849000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.13193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,26]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1111\/tid.13193"],"URL":"https:\/\/doi.org\/10.1111\/tid.13193","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"type":"print","value":"1398-2273"},{"type":"electronic","value":"1399-3062"}],"subject":[],"published":{"date-parts":[[2020,2,26]]},"assertion":[{"value":"2019-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13193"}}