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Episodes diagnosed in adult SOT recipients in 10 participating centers were included. Risk factors for clinical failure (all\u2010cause 7\u2010day mortality and\/or persistent candidemia for \u226572\u00a0hours) and 30\u2010day mortality were investigated by univariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 55 episodes of post\u2010transplant candidemia (32 and 23 of which occurred during the first and second periods). Kidney (38.2%) and liver recipients (30.9%) were the most common populations. <jats:italic>Candida albicans<\/jats:italic> accounted for 27.3% of episodes. The proportion of <jats:italic>C\u00a0glabrata<\/jats:italic> increased over time (18.8% vs 30.4% for the first and second periods). There were no differences in the rate of fluconazole non\u2010susceptible isolates (50.0% vs 60.0%, respectively). Clinical failure and 30\u2010day mortality occurred in 25.5% and 27.3% of episodes and were associated with the severity of candidemia (Pitt score and severe sepsis\/septic shock). Kidney transplantation (unadjusted odds ratio [uOR]: 0.17; 95% confidence interval [CI]: 0.03\u20100.85; <jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a0.020), early catheter removal (uOR: 0.15; 95% CI: 0.03\u20100.76; <jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a0.013), and appropriate early antifungal therapy (uOR: 0.14; 95% CI: 0.02\u20100.89; <jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a0.041) were protective for 30\u2010day mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High rates of non\u2010<jats:italic>albicans<\/jats:italic> species and fluconazole non\u2010susceptibility must be taken into account to optimize therapeutic management and outcomes in SOT recipients with candidemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13195","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T20:03:17Z","timestamp":1571083397000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Candidemia in solid organ transplant recipients in Spain: Epidemiological trends and determinants of outcome"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0315-8001","authenticated-orcid":false,"given":"Mario","family":"Fern\u00e1ndez\u2010Ruiz","sequence":"first","affiliation":[{"name":"Unit of Infectious Diseases Hospital Universitario \"12 de Octubre\" Instituto de Investigaci\u00f3n Hospital \"12 de Octubre\" (imas12) Universidad Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Cardozo","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hospital Clinic IDIBAPS (Institut d\u2019Investigacions Biom\u00e8diques Agust Pi i Sunyer) Universitat de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Salavert","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases Hospital Universitari i Polit\u00e8cnic \u201cLa Fe\u201d Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Aguilar\u2010Guisado","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Microbiology and Preventive Medicine Hospital Universitario Virgen del Roc\u00edo Instituto de Biomedicina de Sevilla (IBIS) Universidad de Sevilla Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5608-3090","authenticated-orcid":false,"given":"Laura","family":"Escol\u00e0\u2010Verg\u00e9","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0697-3992","authenticated-orcid":false,"given":"Patricia","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Infectious Diseases Hospital General Universitario \u201cGregorio Mara\u00f1\u00f3n\u201d Instituto de Investigaci\u00f3n Sanitaria \u201cGregorio Mara\u00f1\u00f3n\u201d Universidad Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Gioia","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hospital Universitario \u201cRam\u00f3n y Cajal\u201d IRYCIS (Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria) Universidad de Alcal\u00e1 Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Montejo","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases Hospital Universitario Cruces, Barakaldo Universidad del Pa\u00eds Vasco Bilbao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Merino","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Hospital Universitario Cl\u00ednico \u201cSan Carlos\u201d Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Cuervo","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hospital Universitari de Bellvitge IDIBELL (Institut D\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge) Universitat de Barcelona Barcelona 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