{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:24:49Z","timestamp":1790267089585,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T00:00:00Z","timestamp":1572998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To characterize the clinical presentation and outcomes of invasive mold infections (IMI) in solid organ transplant (SOT) recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Inclusion of all SOT recipients with IMI diagnosed between 2008 and 2016 at a referral center for SOT. Univariable analyses identified factors associated with death at one year, and logistic regression models retained independent predictors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 1739 patients that received a SOT during this period, 68 developed IMI (invasive aspergillosis [IA] in 58). Cumulative incidence of IMI at 1\u00a0year ranged from 1.2% to 18.8% (kidney and heart transplantation, respectively). At baseline, compared with other IMI, the need for vasoactive drugs was more frequent in patients with IA. During follow\u2010up, 35 patients (51%) were admitted to the ICU and required mechanical ventilation (n\u00a0=\u00a027), vasoactive drugs (n\u00a0=\u00a031), or renal replacement therapy (n\u00a0=\u00a031). The need for vasoactive drugs (OR 7.34; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.003) and a positive direct examination (OR 10.1; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.004) were independently associated with the risk of death at 1\u00a0year in patients with IA (n\u00a0=\u00a033; 57%)<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Characteristics of IMI at presentation varied according to the underlying transplanted organ and the mold species. Following IA, one\u2010year mortality may be predicted by the need for hemodynamic support and initial fungal load.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13200","type":"journal-article","created":{"date-parts":[[2019,10,20]],"date-time":"2019-10-20T15:08:07Z","timestamp":1571584087000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Outcomes of solid organ transplant recipients with invasive aspergillosis and other mold infections"],"prefix":"10.1111","volume":"22","author":[{"given":"C\u00e9dric","family":"Farges","sequence":"first","affiliation":[{"name":"Service de Parasitologie \u2010 Mycologie Institut F\u00e9d\u00e9ratif de biologie H\u00f4pital Purpan Centre Hospitalier Universitaire de Toulouse Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Cointault","sequence":"additional","affiliation":[{"name":"D\u00e9partement de N\u00e9phrologie et Transplantation d\u2019organes H\u00f4pital Rangueil Centre Hospitalier Universitaire de Toulouse Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marl\u00e8ne","family":"Murris","sequence":"additional","affiliation":[{"name":"Service de Pneumologie H\u00f4pital Larrey Centre Hospitalier Universitaire de Toulouse Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Lavayssiere","sequence":"additional","affiliation":[{"name":"D\u00e9partement de N\u00e9phrologie et Transplantation d\u2019organes H\u00f4pital Rangueil Centre Hospitalier Universitaire de Toulouse Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sh\u00e9razade","family":"Lakhdar\u2010Ghazal","sequence":"additional","affiliation":[{"name":"Service de Parasitologie \u2010 Mycologie Institut F\u00e9d\u00e9ratif de biologie H\u00f4pital Purpan Centre Hospitalier Universitaire de Toulouse Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3115-868X","authenticated-orcid":false,"given":"Arnaud","family":"Del Bello","sequence":"additional","affiliation":[{"name":"D\u00e9partement de N\u00e9phrologie et Transplantation d\u2019organes H\u00f4pital Rangueil Centre Hospitalier Universitaire de Toulouse Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Laure","family":"Hebral","sequence":"additional","affiliation":[{"name":"D\u00e9partement de N\u00e9phrologie et Transplantation d\u2019organes H\u00f4pital Rangueil Centre Hospitalier Universitaire de Toulouse Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Esposito","sequence":"additional","affiliation":[{"name":"D\u00e9partement de N\u00e9phrologie et Transplantation d\u2019organes H\u00f4pital Rangueil Centre Hospitalier Universitaire de Toulouse Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010B\u00e9atrice","family":"Nogier","sequence":"additional","affiliation":[{"name":"D\u00e9partement de N\u00e9phrologie et Transplantation d\u2019organes H\u00f4pital Rangueil Centre Hospitalier Universitaire de Toulouse Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Sallusto","sequence":"additional","affiliation":[{"name":"Service d\u2019Urologie H\u00f4pital Rangueil Centre Hospitalier Universitaire de Toulouse Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Iriart","sequence":"additional","affiliation":[{"name":"Service de Parasitologie \u2010 Mycologie Institut F\u00e9d\u00e9ratif de biologie H\u00f4pital Purpan Centre Hospitalier Universitaire de Toulouse Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Charpentier","sequence":"additional","affiliation":[{"name":"Service de Parasitologie \u2010 Mycologie Institut F\u00e9d\u00e9ratif de biologie H\u00f4pital Purpan Centre Hospitalier Universitaire de Toulouse Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joelle","family":"Guitard","sequence":"additional","affiliation":[{"name":"D\u00e9partement de N\u00e9phrologie et Transplantation d\u2019organes H\u00f4pital Rangueil Centre Hospitalier Universitaire de Toulouse Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Muscari","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Digestive H\u00f4pital Rangueil Centre Hospitalier Universitaire de Toulouse Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Dambrin","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Cardio\u2010Vasculaire H\u00f4pital Rangueil Centre Hospitalier Universitaire de Toulouse Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydie","family":"Porte","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses et Tropicales H\u00f4pital Purpan Centre Hospitalier Universitaire de Toulouse Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1930-8964","authenticated-orcid":false,"given":"Nassim","family":"Kamar","sequence":"additional","affiliation":[{"name":"D\u00e9partement de N\u00e9phrologie et Transplantation d\u2019organes H\u00f4pital Rangueil Centre Hospitalier Universitaire de Toulouse Toulouse France"},{"name":"IFR\u2013BMT Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1043 Universit\u00e9 Paul Sabatier Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Cassaing","sequence":"additional","affiliation":[{"name":"Service de Parasitologie \u2010 Mycologie Institut F\u00e9d\u00e9ratif de biologie H\u00f4pital Purpan Centre Hospitalier Universitaire de Toulouse Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0553-0927","authenticated-orcid":false,"given":"Stanislas","family":"Faguer","sequence":"additional","affiliation":[{"name":"D\u00e9partement de N\u00e9phrologie et Transplantation d\u2019organes H\u00f4pital Rangueil Centre Hospitalier Universitaire de Toulouse Toulouse France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale UMR 1048 Institut des Maladies M\u00e9taboliques et Cardiovasculaires Universit\u00e9 Paul Sabatier Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12981"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-013-0539-3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks266"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13837"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/651262"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03548.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2007.140087"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.12.28"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2010.00492.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/13693780400020113"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/345441"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/430602"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3062.2002.t01-2-02002.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02978.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2015.03.040"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis195"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1086\/605445"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1710.110087"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2012.09.059"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12129"},{"issue":"3","key":"e_1_2_8_22_1","first-page":"269","article-title":"Epidemiological features of invasive mold infections among solid organ transplant recipients: PATH Alliance\u00ae registry analysis","volume":"55","author":"Husain S","year":"2017","journal-title":"Med Mycol"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1086\/588660"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12898"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31829e6d7b"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12808"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30274-1"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4731-2"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-011-2344-8"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12765"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2012.02.018"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13200","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.13200","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T05:22:57Z","timestamp":1694064177000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.13200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,6]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/tid.13200"],"URL":"https:\/\/doi.org\/10.1111\/tid.13200","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,6]]},"assertion":[{"value":"2019-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13200"}}