{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:48:00Z","timestamp":1761709680521,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T00:00:00Z","timestamp":1573430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007311","name":"Deutsche Kinderkrebsstiftung","doi-asserted-by":"publisher","award":["DKS 2011.5"],"award-info":[{"award-number":["DKS 2011.5"]}],"id":[{"id":"10.13039\/501100007311","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adenovirus (HAdV) infections confer a high risk of morbidity and mortality for immunocompromised patients after stem cell transplantation (SCT). Treatment with standard antiviral drugs is of limited efficacy and associated with a high rate of adverse effects. HAdV\u2010specific T cells are crucial for sustained viral elimination and the efficacy of adoptive T\u2010cell therapy with donor\u2010derived HAdV\u2010specific T cells has been reported by several investigators. Here, we report our experience with the transfer of HAdV\u2010specific T cells specific for penton, which was recently identified as an immunodominant target of T cells, and hexon in a 14\u2010year\u2010old boy after T\u2010cell\u2010depleted haploidentical SCT for myelodysplastic syndrome (MDS). He developed severe HAdV\u2010associated enteritis complicated by acute graft\u2010versus\u2010host disease (GvHD). The patient received ten infusions of allogeneic HAdV\u2010specific T cells manufactured from the haploidentical stem cell donor using the CliniMacs Interferon\u2010\u03b3 (IFN\u2010\u03b3) cytokine capture and immunomagnetic selection. Initially, T cells were generated against the immunodominant target hexon and in subsequent transfers dual antigen\u2010specific T cells against hexon and penton were applied. T\u2010cell transfers were scheduled individually tailored to current immunosuppressive treatment. Each transfer was followed by reduction of HAdV load in peripheral blood and clinical improvement. Importantly, T\u2010cell responses to both penton and hexon pools emerged in patient blood after repetitive transfers. Unfortunately, the patient experienced bacterial sepsis, and in this context, severe GvHD requiring intensive immunosuppression followed by secondary progression of HAdV infection. The patient succumbed to multiorgan failure 283\u00a0days after SCT. This case demonstrates the feasibility of HAdV\u2010specific T\u2010cell transfer even in the presence of immunosuppressive treatment. Targeting of multiple immunodominant viral proteins may prove valuable in patients with complicated HAdV infections.<\/jats:p>","DOI":"10.1111\/tid.13201","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T19:25:17Z","timestamp":1571858717000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Transfer of Hexon\u2010 and Penton\u2010selected adenovirus\u2010specific T cells for refractory adenovirus infection after haploidentical stem cell transplantation"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3293-2550","authenticated-orcid":false,"given":"Rebecca E.","family":"Schultze\u2010Florey","sequence":"first","affiliation":[{"name":"Pediatric Hematology and Oncology Hannover Medical School Hannover Germany"},{"name":"Integrated Research and Treatment Center Transplantation (IFB\u2010Tx) Hannover Medical School Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Tischer\u2010Zimmermann","sequence":"additional","affiliation":[{"name":"Integrated Research and Treatment Center Transplantation (IFB\u2010Tx) Hannover Medical School Hannover Germany"},{"name":"Institute for Transfusion Medicine Hannover Medical School Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010Gert","family":"Heuft","sequence":"additional","affiliation":[{"name":"Institute for Transfusion Medicine Hannover Medical School Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Priesner","sequence":"additional","affiliation":[{"name":"Institute for Cellular Therapeutics Hannover Medical School Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britta","family":"Lamottke","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Hannover Medical School Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Heim","sequence":"additional","affiliation":[{"name":"Institute for Virology Hannover Medical School Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Sauer","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Hannover Medical School Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl\u2010Walter","family":"Sykora","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Hannover Medical School Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Blasczyk","sequence":"additional","affiliation":[{"name":"Institute for Transfusion Medicine Hannover Medical School Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britta","family":"Eiz\u2010Vesper","sequence":"additional","affiliation":[{"name":"Integrated Research and Treatment Center Transplantation (IFB\u2010Tx) Hannover Medical School Hannover Germany"},{"name":"Institute for Transfusion Medicine Hannover Medical School Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britta","family":"Maecker\u2010Kolhoff","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Hannover Medical School Hannover Germany"},{"name":"Integrated Research and Treatment Center Transplantation (IFB\u2010Tx) Hannover Medical School Hannover 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