{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T21:41:49Z","timestamp":1771882909294,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T00:00:00Z","timestamp":1573430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Human herpesvirus\u20106B (HHV\u20106B) infection after allogenic hematopoietic stem cell transplantation (allo\u2010HSCT) is known to be associated with post\u2010transplant limbic encephalitis in adults. Meanwhile, the association between HHV\u20106B infection and central nervous system complications remains unclear in pediatric allo\u2010HSCT patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, HHV\u20106B infection was monitored for more than 50\u00a0days after HSCT using virus isolation and real\u2010time PCR. Clinical information such as patient background and encephalitis status was collected retrospectively from medical records. Risk factors for HHV\u20106B infection were determined by the Cox proportional hazards model, and the clinical features of HHV\u20106B encephalitis in pediatric allo\u2010HSCT patients were elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Human herpesvirus\u20106B infection was observed in 74 (33.8%) of 219 patients at 3\u201047\u00a0days (median 18, interquartile range 13\u201020). Risk factors identified in multivariable analysis were hematological malignancy (hazards ratio [HR], 5.0; 95% confidence interval [CI], 2.3\/12.5; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001), solid tumor (HR, 4.8; CI, 1.5\/16.3; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0104), unrelated donor (HR, 2.1; CI, 1.0\/4.6; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0378), and sex\u2010mismatched donor (HR 1.8; CI, 1.1\/3.0; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0257). HHV\u20106B encephalitis occurred in only one of the 219 patients (0.46%); this patient demonstrated the typical clinical course of posterior reversible encephalopathy syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hematological malignancy, solid tumor, unrelated donor, and sex\u2010mismatched donor were significant risk factors for HHV\u20106B infection after pediatric allo\u2010HSCT. In pediatric allo\u2010HSCT patients, the incidence of HHV\u20106B encephalitis was low and the clinical features differed from those in adult patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13203","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T07:59:52Z","timestamp":1571990392000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Human herpesvirus\u20106B infection in pediatric allogenic hematopoietic stem cell transplant patients: Risk factors and encephalitis"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2847-3374","authenticated-orcid":false,"given":"Hiroki","family":"Miura","sequence":"first","affiliation":[{"name":"Department of Pediatrics Fujita Health University School of Medicine Toyoake 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