{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T03:06:40Z","timestamp":1761102400240,"version":"3.41.2"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T00:00:00Z","timestamp":1573776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Conflicting data have been published as to the risk of cytomegalovirus (CMV) DNAemia and CMV disease in patients undergoing haploidentical hematopoietic stem cell transplantation (haplo\u2010HSCT) with post\u2010transplantation cyclophosphamide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a multicenter retrospective study including 118 patients subjected to unmanipulated haplo\u2010HSCT to further clarify this issue. An historic cohort comprising 165 patients undergoing other transplant modalities (HLA\u2010matched related, matched unrelated or mismatched) was built for comparison purposes. Plasma CMV DNA monitoring was performed using two highly sensitive real\u2010time PCR assays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, the cumulative incidence of CMV DNAemia, recurrent CMV DNAemia, and CMV DNAemia requiring preemptive antiviral therapy in patients undergoing haplo\u2010HSCT was 63.9%, 34.9%, and 50.1%, respectively. These figures were rather comparable for other transplant modalities (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.22,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.13 and<jats:italic>P<\/jats:italic>\u00a0=\u00a0.72, respectively). A trend toward longer duration of episodes and shorter CMV DNA doubling times was observed in haplo\u2010HSCT patients in comparison with other transplant modalities. Furthermore, median CMV DNA peak load was significantly higher in haplo\u2010HSCTs (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.008), yet overall mortality by day 180 and 365 was the same across comparison groups. There were five cases of CMV disease, and all occurred in haplo\u2010HSCT patients. This latter observation is worrying and merits further investigation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence of initial and recurrent episodes of CMV DNAemia either requiring or not antiviral therapy in unmanipulated haplo\u2010HSCT was comparable to other transplant modalities in our cohort.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13206","type":"journal-article","created":{"date-parts":[[2019,11,2]],"date-time":"2019-11-02T07:19:10Z","timestamp":1572679150000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Incidence, features, and outcomes of cytomegalovirus DNAemia in unmanipulated haploidentical allogeneic hematopoietic stem cell transplantation with post\u2010transplantation cyclophosphamide"],"prefix":"10.1111","volume":"22","author":[{"given":"Dixie","family":"Huntley","sequence":"first","affiliation":[{"name":"Microbiology Service Hospital Cl\u00ednico Universitario INCLIVA ResearchInstitute Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estela","family":"Gim\u00e9nez","sequence":"additional","affiliation":[{"name":"Microbiology Service Hospital Cl\u00ednico Universitario INCLIVA ResearchInstitute Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jes\u00fas","family":"Pascual","sequence":"additional","affiliation":[{"name":"Hematology Service Hospital Regional Universitario M\u00e1laga Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Hern\u00e1ndez\u2010Boluda","sequence":"additional","affiliation":[{"name":"Hematology Service Hospital Cl\u00ednico Universitario INCLIVA ResearchInstitute Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Gago","sequence":"additional","affiliation":[{"name":"Hematology Service Hospital Regional Universitario M\u00e1laga Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes","family":"V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Hematology Service Hospital Cl\u00ednico Universitario Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8533-2562","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Pi\u00f1ana","sequence":"additional","affiliation":[{"name":"Hematology Service Hospital Cl\u00ednico Universitario INCLIVA ResearchInstitute Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Hematology Service Hospital Cl\u00ednico Universitario Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariadna","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Hematology Service Hospital Cl\u00ednico Universitario INCLIVA ResearchInstitute Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Serrano","sequence":"additional","affiliation":[{"name":"Hematology Service Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Hematology Service Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliseo","family":"Albert","sequence":"additional","affiliation":[{"name":"Microbiology Service Hospital Cl\u00ednico Universitario INCLIVA ResearchInstitute Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Solano","sequence":"additional","affiliation":[{"name":"Hematology Service Hospital Cl\u00ednico Universitario INCLIVA ResearchInstitute Valencia Spain"},{"name":"Department of Medicine School of Medicine University of Valencia Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3010-4110","authenticated-orcid":false,"given":"David","family":"Navarro","sequence":"additional","affiliation":[{"name":"Microbiology Service Hospital Cl\u00ednico Universitario INCLIVA ResearchInstitute Valencia Spain"},{"name":"Department of Microbiology School of Medicine University of Valencia Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.03.005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-344853"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-01-623991"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.44.3523"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-04-639831"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2217\/fvl.14.102"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(15)00289-6"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-11-679639"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy138"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12717"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz490"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12629"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.149880"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit475"},{"key":"e_1_2_8_16_1","doi-asserted-by":"crossref","first-page":"e13096","DOI":"10.1111\/tid.13096","article-title":"Haploidentical allogeneic hematopoietic stem cell transplantation increases the risk of cytomegalovirus infection in adult patients with acute leukemia","volume":"20","author":"Lin CH","year":"2019","journal-title":"Transpl Infect Dis"},{"key":"e_1_2_8_17_1","first-page":"10","article-title":"Risk factors for cytomegalovirus DNAemia following haploidentical stem cell transplantation and its association with host hepatitis B virus serostatus","volume":"75","author":"Chen Y","year":"2016","journal-title":"J ClinVirol"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.09.018"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2016.08.003"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2016.216"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-015-2423-y"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-011-9630-7"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12365"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-017-0016-1"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.06.019"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.08.013"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2012.10.010"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2010.03.015"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2015.303"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.08.014"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197410000-00001"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14754"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2016.09.008"},{"key":"e_1_2_8_34_1","first-page":"2741","article-title":"Navarro D cytomegalovirus infection management in allogeneic stem cell transplant recipients: a national survey in Spain","volume":"53","author":"Solano C","year":"2015","journal-title":"J ClinMicrobiol"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2019.03.005"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftid.13206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.13206","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T11:37:33Z","timestamp":1695382653000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.13206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,15]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/tid.13206"],"URL":"https:\/\/doi.org\/10.1111\/tid.13206","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"type":"print","value":"1398-2273"},{"type":"electronic","value":"1399-3062"}],"subject":[],"published":{"date-parts":[[2019,11,15]]},"assertion":[{"value":"2019-09-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13206"}}