{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T09:20:44Z","timestamp":1794216044428,"version":"4.8.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T00:00:00Z","timestamp":1574726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>BK polyomavirus\u2010associated nephropathy (PyVAN) is an important complication after kidney transplantation. Prevalence ranges from 1% to 10%, and graft loss occurs in approximately 50% of the cases. There is no effective treatment, so early viral detection with immunosuppression tapering is the current strategy to prevent PyVAN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To verify the frequency of PyVAN in a single center and evaluate the response to immunosuppressive adjustments through graft survival analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective evaluation of a cohort of kidney transplant recipients with biopsy\u2010proven PyVAN, compared with no\u2010PyVAN patients regarding clinical aspects, immunosuppression, and graft survival over at least 2\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 1404 kidney transplants analyzed in the study period, 58 with biopsy\u2010proven PyVAN. Cumulative incidence was 4.1%. Median time from transplantation to PyVAN diagnosis was 6 (1\u201041) months. PyVAN was associated with recipient male gender (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.041) and deceased donation (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.005). Graft survival was inferior for PyVAN compared to no\u2010PyVAN patients, 81.8% vs 75.2%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.019. Thirteen (22.4%) PyVAN patients lost their grafts, nine (15.5%) losses attributed to BKPyV infection. Three patients with BKPyV\u2010associated graft losses were submitted to a successful second kidney transplant, with no evidence of viral replication during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PyVAN still is an important cause of kidney graft failure. Even though implementing active vigilance and immunosuppressive adjustment, this real\u2010life single\u2010center study demonstrated inferior graft survival in PyVAN patients compared to non\u2010PyVAN.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13213","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T08:43:59Z","timestamp":1573721039000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["BK Polyomavirus\u2010associated nephropathy managed by screening policy in a real\u2010life setting"],"prefix":"10.1111","volume":"22","author":[{"given":"Fernanda Vianna Vacilotto","family":"Raupp","sequence":"first","affiliation":[{"name":"Post Graduation Program in Pathology Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6784-0894","authenticated-orcid":false,"given":"Gisele","family":"Meinerz","sequence":"additional","affiliation":[{"name":"Post Graduation Program in Pathology Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre Porto Alegre Brazil"},{"name":"Department of Nephrology and Kidney Transplantation Santa Casa de Miseric\u00f3rdia de Porto Alegre Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3778-4473","authenticated-orcid":false,"given":"Cynthia Keitel","family":"da Silva","sequence":"additional","affiliation":[{"name":"Post Graduation Program in Pathology Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre Porto Alegre Brazil"},{"name":"Department of Nephrology and Kidney Transplantation Santa Casa de Miseric\u00f3rdia de Porto Alegre Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3524-3144","authenticated-orcid":false,"given":"Patr\u00edcia Campos d\u2019Almeida","family":"Bianco","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation Santa Casa de Miseric\u00f3rdia de Porto Alegre Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2099-5685","authenticated-orcid":false,"given":"Jo\u00e3o Carlos","family":"Goldani","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation Santa Casa de Miseric\u00f3rdia de Porto Alegre Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla Lais","family":"Pegas","sequence":"additional","affiliation":[{"name":"Post Graduation Program in Pathology Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre Porto Alegre Brazil"},{"name":"Department of Pathology Santa Casa de Miseric\u00f3rdia de Porto Alegre Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josiane Borges","family":"Stolfo","sequence":"additional","affiliation":[{"name":"Department of Pathology Santa Casa de Miseric\u00f3rdia de Porto Alegre Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7394-1501","authenticated-orcid":false,"given":"Valter Duro","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation Santa Casa de Miseric\u00f3rdia de Porto Alegre Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5519-8224","authenticated-orcid":false,"given":"Elizete","family":"Keitel","sequence":"additional","affiliation":[{"name":"Post Graduation Program in Pathology Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre Porto Alegre Brazil"},{"name":"Department of Nephrology and Kidney Transplantation Santa Casa de Miseric\u00f3rdia de Porto Alegre Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.00980.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000156165.83160.09"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000040"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020439"},{"issue":"3","key":"e_1_2_6_6_1","first-page":"S1","article-title":"KDIGO clinical practice guideline for the care of kidney transplant recipients","volume":"9","author":"KIDIGO. 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