{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:23:03Z","timestamp":1787016183066,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T00:00:00Z","timestamp":1580947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hemophagocytic lymphohistiocytosis (HLH) is a disorder of immune regulation, manifested by fever, pancytopenia, hyperferritiniemia, hypertriglyceridemia, and extensive hemophagocytosis involving the bone marrow and spleen. HLH can occur in adults with an underlying hematopoietic malignancy, or with systemic infections. HLH following hematopoietic\u00a0stem cell transplantation\u00a0(HSCT) is unusual, and the diagnosis may be challenging particularly because the diagnostic criteria in the HLH\u20102004 guidelines overlap with common post\u2010transplant complications such as engraftment syndrome, graft\u2010vs\u2010host disease, and infections. HLH is commonly triggered by viral, bacterial and, less commonly, parasitic infections. Following HSCT, patients with latent Toxoplasma infection may develop systemic disease secondary to reactivation, and rarely this may lead to a HLH physiology, with a very high mortality rate. Herein we describe the successful management of disseminated toxoplasmosis associated with life\u2010threatening HLH using tocilizumab and antimicrobial therapy.<\/jats:p>","DOI":"10.1111\/tid.13242","type":"journal-article","created":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T11:17:11Z","timestamp":1577963831000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Toxoplasma\u2010induced hemophagocytic lymphohistiocytosis after haploidentical allogeneic stem cell transplantation"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1000-1643","authenticated-orcid":false,"given":"Gabriela","family":"Sanchez\u2010Petitto","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology Greenebaum Comprehensive Cancer Center University of Maryland School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noa G.","family":"Holtzman","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology National Institutes of Health Bethesda MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Bukhari","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Greenebaum Comprehensive Cancer Center University of Maryland School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases University of Maryland School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan K.","family":"Morales","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases University of Maryland School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhurima","family":"Koka","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Maryland School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean A.","family":"Yared","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Greenebaum Comprehensive Cancer Center University of Maryland School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh","family":"Dahiya","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Greenebaum Comprehensive Cancer Center University of Maryland School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron P.","family":"Rapoport","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Greenebaum Comprehensive Cancer Center University of Maryland School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy M.","family":"Hardy","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Greenebaum Comprehensive Cancer Center University of Maryland School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07863.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0172"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-06-788349"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10245332.2018.1491093"},{"issue":"3","key":"e_1_2_5_6_1","first-page":"e1070","article-title":"Acute cytomegalovirus (CMV) infection associated with hemophagocytic lymphohistiocytosis (HLH) in an immunocompetent host 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